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Antidepressant Treatment at an Inner City Asthma Clinic

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A 12-week, randomized, double-blind, parallel-group, placebo-controlled acute phase trial of escitalopram is proposed in 222 persons with asthma and Major Depressive Disorder (MDD). This sample will consist of 80 stratified into the High severity group which will consist of a baseline score > or =

Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis

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Major depressive disorder (MDD) is a highly prevalent, chronic disabling condition with substantial morbidity and mortality. Depression currently is the fourth leading cause of global burden of disease (DALYs) and disability worldwide, and is expected to be second by 20201. Around one in eight

CATIE-Alzheimer's Disease Trial

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There are four phases. Phase I: In the initial treatment phase (Phase 1), patients will be randomized to one of the three atypical antipsychotics or placebo in the ratio 100:100:100:150 respectively. After two weeks, the investigator can move the patient to the next phase because of lack of efficacy

Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain

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Pain continues to be a major problem in patients with cancer, affecting 25% to 30% of patients with recently diagnosed cancers. The incidence of pain in advanced stages of cancer approaches 70% to 80%. There are a number of reasons that patients with cancer experience chronic pain either related to

Treatment Follow-up Study

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Over a two year period, 800 children and adolescents between the ages of 6 - 17 years old who have received a new prescription for an antidepressant will be recruited from families receiving care at Nationwide Children's Hospital or Community Physician Practices affiliated with Nationwide Children's

Histamine Responsiveness in McCune-Albright Syndrome

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Objectives of this study are to determine if: 1. Patients with McCune-Albright syndrome differ from unaffected controls in wheal and flare response to histamine and codeine. 2. Affected skin will differ from unaffected skin in wheal and flare response to histamine and codeine. 3. IgE and IL-4 levels

Adapting Project UPLIFT for Blacks in Georgia

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Project UPLIFT is a manualized intervention that includes a script for use by the telephone facilitators in leading activities and discussions; use of a script is possible because the delivery is not face-to-face. Activities and discussions are designed to increase knowledge about epilepsy and

Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women?

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BACKGROUND: Bipolar Affective Disorder remains an illness with high morbidity and mortality. Mood stabilizers such as lithium and sodium valproate have been described as having their anti-manic effect by targeting protein kinase C (PKC) isozymes (Manji and Lenos, 1999). In rats chronically treated

Early Training of Attention After Acquired Brain Injury

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STUDY METHODS The primary objectives of the study were: 1. In the acute stage, to evaluate the effectiveness of APT measured by the changes in performance in the attention measure, Paced Auditory Serial Addition Test, (PASAT) evaluated by Statistical Process Control 2. In the postacute stage, to

Comparison Between Two Different Antibiotic Regimens for the Placement of Dental Implants

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Introduction After the discovery of penicillin as an antimicrobial agent in 1928, and later methicillin, an important improvement of the prognosis of antimicrobial therapies occurred. However, an increased trend in antibiotic resistance among community-acquired pathogens has been observed over the

Biobehavioral Bases & Management of Type 2 Diabetes

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This project will be conducted on type 2 diabetic patients. Patients meeting eligibility criteria will be randomized to SC or the CALM-D condition, which includes diet and exercise counseling and coping skills training that in part is intended to facilitate medication adherence. Both CALM-D and SC

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