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Anti-inflammatory Therapy With Anakinra in Newly Diagnosed Type 1 Diabetes

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Type 1 diabetes mellitus (T1D) is caused by autoimmune and autoinflammatory destruction of the insulin-producing beta cells in the pancreatic islets of Langerhans. Historically, treatment for this condition has consisted of insulin replacement therapy and dietary modification. Recent studies have

Methylprednisolone Before Fludeoxyglucose-Labeled Positron Emission Tomography in Patients With Lung Cancer

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PRIMARY OBJECTIVES: I. To assess whether premedication with a corticosteroid may reduce false positive findings on fluorodeoxyglucose (fludeoxyglucose F 18 [FDG[) PET/computed tomography (CT) scans in lung cancer patients, by reducing radiotracer uptake in thoracic lymph nodes related to

Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)

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Fetal complete (3°) atrioventricular block (AVB), identified in the 2nd trimester in an otherwise normally developing heart, is almost universally associated with maternal anti-Ro autoantibodies, which transcytose the placenta via the trophoblastic IgG receptor, FcγRn. The burden of 3° AVB is

Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta.

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Significance: Complex surgery of the ascending thoracic aorta and the aortic arch requires use of cardiopulmonary bypass (CPB) with moderate or profound total body hypothermia and circulatory arrest. As expected, coagulation disorder can be common and severe requiring multiple transfusions of blood

Tolerability, Efficacy and Mucosal Inflammation Associated With Orally Administered Colon Cleansing for Colonoscopy

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There are several published trials of different colon cleansing agents for colonoscopy (which is the investigation of choice for visualisation of the colonic mucosa) which compare different regimens. However, a recent published meta-analysis has shown that most audits and studies were underpowered

Dexamethasone and Respiratory Function After Mastectomy

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Controlled clinical trial will be performed in 120 surgical patients treated for breast cancer, conducted from Nov 2014 to Nov 2015. Patients will be divided in three groups: Group 1 consisted in patients who underwent conservative breast with axillary lymph node dissection, group 2 in patients with

Therapeutic Approaches to Malnutrition Enteropathy

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Over the last two decades, three key developments in the approach to treatment have improved the outcome of SAM: standardised management protocols, ready to use therapeutic food (RUTF), and community management of acute malnutrition (CMAM). CMAM has four components, namely, community mobilization

Evaluating Safety & Efficacy of Apremilast in the Treatment of Cutaneous Disease in Patients With Recalcitrant Dermatomyositis

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1. Sponsor Name (PI): Carole Bitar, MD 2. Sub-PI: Erin Boh, MD, PhD; Brittany Stumpf, MD; Collaborator: Nakhle Saba, MD 3. # of Participants Sites: 1, Tulane University 4: Participant Countries: United States II. PRODUCT INFORMATION 1. Study Title: A phase 2, open label single arm study for

The Effect of Curcumin on the Development of Prednisolone-induced Hepatic Insulin Resistance

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AIMS OF STUDY The aim of this study is to investigate whether ingestion of curcumin will prevent hepatic insulin resistance (assessed by homeostatic model assessment of insulin resistance (HOMA-IR)) induced by short-term oral glucocorticoid (prednisolone) administration in overweight and obese

Evaluation of the Medial Parapatellar Knee Injection Technique

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Injection into the knee joint, although considered a remedial procedure by much of the medical community, is not as easy a procedure to reproducibly and accurately perform as one would believe. Numerous authors have estimated that between 20 to over 30 percent of knee injection procedures fail to

Comparison Between Two Different Antibiotic Regimens for the Placement of Dental Implants

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Introduction After the discovery of penicillin as an antimicrobial agent in 1928, and later methicillin, an important improvement of the prognosis of antimicrobial therapies occurred. However, an increased trend in antibiotic resistance among community-acquired pathogens has been observed over the

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