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Factors associated with false-positive and false-negative fecal immunochemical test results for colorectal cancer screening.

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BACKGROUND Certain subgroups have higher rates of false fecal immunochemical test (FIT) results, yet few studies have addressed this topic. OBJECTIVE To identify demographic factors associated with false-positive and false-negative FIT results in colorectal cancer screening. METHODS Retrospective

Participant-Related Risk Factors for False-Positive and False-Negative Fecal Immunochemical Tests in Colorectal Cancer Screening: Systematic Review and Meta-Analysis.

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OBJECTIVE Colorectal cancer (CRC) screening using fecal immunochemical tests (FIT) may reduce CRC-related mortality but its effectiveness is influenced by the limited accuracy of FIT. Identifying individuals at increased risk of a false FIT result could improve screening, but the available evidence

A tale of two therapies lipid-lowering vs anti-inflammatory therapy - a false dichotomy?

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True or false? Challenges and recent highlights in the development of aspirin prodrugs.

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Aspirin is a widely used medicine for a variety of indications. It is unique amongst non-steroidal anti-inflammatory drugs (NSAIDs) in that it causes irreversible acetylation of COX enzymes. Like all NSAIDs however, aspirin causes severe gastrointestinal side-effects, in particular with chronic

Folic acid, inflammation, and atherosclerosis: false hopes or the need for better trials?

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An increasing body of evidence supports the existence of a strong link between inflammation, endothelial dysfunction, and the onset and progression of atherosclerosis. However, a cause-effect relationship between these phenomena has not been demonstrated yet. Although some inflammatory markers, such

False-positive results in metagenomic virus discovery: a strong case for follow-up diagnosis.

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A viral metagenomic approach using virion enrichment, random amplification and next-generation sequencing was used to investigate an undiagnosed cluster of dairy cattle presenting with high persistent fever, unresponsive to anti-microbial and anti-inflammatory treatment, diarrhoea and redness of

Proton-pump inhibitors are associated with a high false-positivity rate in faecal immunochemical testing

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Background: False-positivity rates in faecal immunochemical test (FIT) can be affected by drug exposure. We aimed to assess the association between proton pump inhibitors (PPI) consumption and false positive (FP) results in a colorectal

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

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There is increasing scientific interest in the field of vitamin D research, moving the focus beyond bone health to other disease processes. Low circulating vitamin D levels have been reported as a risk factor for several pathophysiologically divergent diseases, including cancers, diabetes, CVD,

Do aspirin and nonsteroidal anti-inflammatory drugs cause false-positive fecal occult blood test results? A prospective study in a cohort of veterans.

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OBJECTIVE To determine whether use of regular aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) is a risk factor for a false-positive fecal occult blood test result. METHODS Consecutive patients referred for colonoscopy for a positive fecal occult blood test result at a Veterans Affairs

IBD Patients Could Be Silent Carriers for Novel Coronavirus and Less Prone to its Severe Adverse Events: True or False?

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Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract. The goal of IBD treatment is to reduce the inflammation period and induce long-term remission. Use of anti-inflammatory drugs including corticosteroids, immunosuppressants and biologicals, is often the first step

Development of an ear edema model of contact hypersensitivity to avoid false-positive results due to interactions between hapten and test agents.

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Ear edema models are regularly used for topical testing of antiinflammatory compounds. However, test compounds are usually applied simultaneously with proinflammatory agents at the same site which may result in mutual interactions. In order to avoid the occurrence of false antiinflammatory effects,

Investigation of interference by nonsteroidal anti-inflammatory drugs in urine tests for abused drugs.

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Anecdotal and uncontrolled studies have suggested that nonsteroidal anti-inflammatory drugs produce false-positive results in immunoassay urine tests for some drugs of abuse. This study was performed in 60 volunteers who took ibuprofen as either a single 400-mg dose, or 200 mg three times a day, or

Determination of 105 antibiotic, anti-inflammatory, antiparasitic agents and tranquilizers by LC-MS/MS based on an acidic QuEChERS-like extraction.

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A procedure for screening 105 veterinary drugs in foods by liquid chromatography tandem mass-spectrometry (LC-MS/MS) is presented. Its scope encompasses raw materials of animal origin (milk, meat, fish, egg and fat) but also related processed ingredients and finished products commonly used and

Traditional Medicinal Oils Sourced from Birds: Anti-inflammatories and Potential Immunoregulants.

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This chapter describes medicinal oils of animal origin, used in Africa and Australasia both for nutritional and medicinally for treating pain and inflammation. Analytical studies of composition, bio-efficacy and their remarkable safety are described. For obtaining reproducible benefits, it is very

The use of thermography in the evaluation of the anti-inflammatory activity of feprazone on rheumatoid arthritis.

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By means of the exploration of patients suffering from an active, unequivocal rheumatoid arthritis it was possible to show the unequivocal, and antiinflammatory effect of 4-phenyl-1,2-diphenyl-3,5-pyrazolidinedione (feprazone, Zepelin). Moreover, it was documented that thermography is a very

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