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false/tyrosine

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[Management in pollinosis and false pollinosis].

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Typical cases of pollen allergen (hayfever, allergic asthma), together with isolated non-respiratory "equivalent" manifestations (urticaria, eye conditions, headache, etc.), are easy to detect on the basis of skin tests and the clinical history. Such manifestations may also occur in "false pollen

Avoiding false discovery in biomarker research.

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Human tyrosine-protein phosphatase non-receptor type substrate 1α (SIRPA) is a surface marker identified in cardiomyocytes differentiated from human embryonic stem cells. Our objective was to determine if circulating SIRPA levels can serve as a biomarker of cardiac injury in children undergoing open

False-positive dopamine in pheochromocytoma treated with tyrosine derivative.

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Fusion proteins could generate false positives in peptide phage display.

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Fusion proteins are frequently used in the functional characterization of newly discovered proteins and to identify interacting partners. In our study of hPTP1E, a cytosolic protein tyrosine phosphatase, we used glutathione S-transferase (GST)-fusion protein of the second PDZ domain to identify

Microiontophoretic studies of the effects of false transmitter candidates and amphetamine on cerebellar Purkinje cells.

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The effects of microiontophoretic applications of equivalent doses (ejection times and currents) of noradrenaline, amphetamine, octopamine and p-hydroxynorephedrine on the spontaneous firing of Purkinje and unidentified cells in the cerebellum of rats were examined. In addition, the effects of

LuciPHOr: algorithm for phosphorylation site localization with false localization rate estimation using modified target-decoy approach.

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The localization of phosphorylation sites in peptide sequences is a challenging problem in large-scale phosphoproteomics analysis. The intense neutral loss peaks and the coexistence of multiple serine/threonine and/or tyrosine residues are limiting factors for objectively scoring site patterns
A subpopulation of nerve fibers in the rat pituitary intermediate lobe (IL) have been shown to exhibit colocalization of serotonin (5-HT-IR) and tyrosine hydroxylase immunoreactivities and they are sensitive to neurotoxins specific to catecholamine neurons. This study was set out to examine the
The sympathetic innervation in false tendons as a whole and the distribution of the terminal sympathetic nerve fibers in the conduction tissue in the bundle branches is unclear. Therefore, in the present study, false tendons and bundle branch regions of the bovine heart were examined using tyrosine
We compared the screening interpretation of fluorometric analytical results for phenylketonuria (PKU) with tandem mass spectrometry (MS/MS) in filter paper blood spots collected from newborns <24 h of age. In MS/MS, both Phe and Tyr are quantified. Two hundred and eight blood spots collected from

Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics.

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The high selectivity and throughput of tandem mass spectrometry allow for rapid identification and localization of various posttranslational protein modifications from complex mixtures by shotgun approaches. Although sequence database search algorithms provide necessary support to process the

Molecular events in the growth inhibition of Bacillus subtilis by D-tyrosine.

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The transformable strain of Bacillus subtilis strain 168 is extremely susceptible to growth inhibition by d-tyrosine. The molecular events associated with the inhibition of growth by d-tyrosine in this strain include the false feedback inhibition and probably the false repression of prephenate

Deranged tyrosine metabolism in cirrhosis.

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In normal individuals, the main route for tyrosine degradation is the hepatic pathway tyrosine→4-hydroxyphenylpyruvic acid→homogentisic acid→CO(2). Quantitatively minor pathways, in large part extrahepatic, are: tyrosinetyramine→octopamine and tyrosine→dopa→catecholamines.In cirrhosis, the main

PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B.

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A highly miniaturized biochemical assay was set up to test a focused set of natural products against the enzymatic activity of protein tyrosine phosphatase 1B (PTP1B). The screen resulted in the identification of the natural product alkaloids, berberine and palmatine as well as α-tocopheryl
BACKGROUND Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. Fetal growth restriction has pathophysiological features in common with preeclampsia. We hypothesised that angiogenesis-related factors in maternal plasma, known to

Manual validation of peptide sequence and sites of tyrosine phosphorylation from MS/MS spectra.

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Mass spectrometry-based analysis of protein phosphorylation has become increasingly powerful over the past decade and has been applied to many different biological systems. One of the most significant concerns facing the phosphoproteomics community and the proteomics field as a whole is the quality
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