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The authors investigated a type of silicone rubber (SR) nipple for toxicity, caused by chemical migrants, on reproduction and pregnancy outcomes. They followed an extraction method (set forth in the 20th revised edition of the United States Pharmacopeia) in which sesame oil was a vehicle. They
Pregnant guinea pigs were administered aspartame (500 mg/kg) in sesame oil by gavage or sesame oil alone between the day of conception and parturition. A nontreated control group was also maintained. There were no statistically significant effects of the treatment on maternal weight gain, litter
Pregnant CD1 mice received 5, 15, 50, 150 mg/kg/day of delta9-THC in sesame oil on days 6-15 of gestation orally by gavage and were killed about one day before expected delivery. Treatment had no effect on the maternal weight gain, prenatal mortality rate, fetal weight, and the frequency of gross