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Inbred Chinese Wuzhishan (WZS) minipig model for soybean glycinin and beta-conglycinin allergy.
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Validated murine models have been built to assess the potential allergenicity of novel proteins. Large animals, such as pigs, share more similarities to humans in physiology and immunology than murine. Among Chinese minipigs, Wuzhishan (WZS) minipigs have the highest inbreeding coefficient, more
[Anaphylactic reactions in WZS minipig orally induced by glycinin].
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OBJECTIVE
To explore the suitable dosage and observation period of anaphylactic reactions in WZS minipigs induced by glycinin (11S).
METHODS
Twelve 45-day-old WZS minipigs were randomly divided into three groups (control group, 4% 11S group and 8% 11S group, n = 4), which were respectively orally
Effects of glycinin on IgE-mediated increase of mast cell numbers and histamine release in the small intestine.
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Soybean allergy represents a significant health threat to individuals with food allergies. Glycinin, the main storage protein in soybean, has been identified as a major food allergen. The present study was conducted to investigate the mechanism of glycinin-induced hypersensitivity in a swine model.
Lipoic acid: an immunomodulator that attenuates glycinin-induced anaphylactic reactions in a rat model.
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The purpose of this study was to evaluate the attenuation effects of consuming a small dose of lipoic acid on soybean glycinin-induced hypersensitivity using a rat model. Sensitized by gavage with glycinin, weaned rats were orally supplemented with the diet containing 12.5 mug of lipoic acid/g (per
Local and systemic immune responses to soybean protein ingestion in early-weaned pigs.
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The development of local and systemic immune responses to soybean proteins was investigated in early-weaned pigs. Pigs were given either antigenic (ASP, n = 10 pigs) or non-antigenic (NASP, n = 8 pigs) soybean products (6 g of protein/d) from d 5 to 9 of age by stomach tube. After weaning at d 21,
Fructo-Oligosaccharide Alleviates Soybean-Induced Anaphylaxis in Piglets by Modulating Gut Microbes.
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Soybean-induced anaphylaxis poses a severe threat to the health of humans and animals. Some commensal bacteria, such as Lactobacillus and Bifidobacteria, can prevent and treat allergic diseases. Prebiotic oligosaccharides, a food/diet additive, can enhance health and performance via
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