glyoxylic acid/necrosis

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Sympathetic hyperinnervation protects vascular smooth muscle cells from necrosis in stroke-prone spontaneously hypertensive rats.

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Sympathetic nerve fiber distribution and vascular smooth muscle morphology were investigated in the ophthalmic artery of stroke-prone spontaneously hypertensive rats (SHRSP) and were compared with those of normotensive Wistar Kyoto (WKY) rats at the age of 120 days. The distribution of fluorescent

Noradrenergic hyperinnervation may inhibit necrosis of coronary arterial smooth muscle cells in stroke-prone spontaneously hypertensive rats.

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Noradrenergic (NA) nerve fibre distribution and vascular smooth muscle morphology were investigated in the coronary artery of stroke-prone spontaneously hypertensive rats (SHRSP). Fluorescent NA nerve fibres of SHRSP aged 10, 30, 60, 90 and 180 days were examined by the glyoxylic acid method and

Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations.

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AWD 12-281 is a potent (IC(50) = 9.7 nM) and highly selective inhibitor of the phosphodiesterase 4 (PDE4) isoenzyme with low affinity to the high-affinity rolipram-binding site. The compound was optimized for topical treatment of asthma, chronic obstructive pulmonary disease (COPD), and allergic

Calcium oxalate, and not other metabolites, is responsible for the renal toxicity of ethylene glycol.

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Ethylene glycol (EG) is nephrotoxic due to its metabolism. Many studies suggest that the toxicity is due to oxalate accumulation, but others have conversely suggested that toxicity results from effects of metabolites such as glycolaldehyde or glyoxylic acid on proximal tubule cells. In vivo studies

Comparative study on cardiotoxic effect of Tinuvin 770: a light stabilizer of medical plastics in rat model.

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Tinuvin 770 [bis(2,2,6,6-tetramethyl-4-piperidinyl) sebacate], is a UV light stabilizer plastic additive used worldwide. It is a component of many plastic materials used in medical and food industries. Earlier studies demonstrated its in vitro L-type Ca2+ channel and nicotinic acetylcholine receptor

Early and late functional and histopathological perturbations in the rabbit ear-artery following local cold injury.

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BACKGROUND These experiments aimed to study the in vivo short and long term neurovascular regeneration after frostbite. METHODS The rabbit central ear-artery was used as the experimental model. The effects on the noradrenergic innervation of the artery were measured in isolated vascular ring

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway.

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The morbidity of nephrolithiasis is 2-3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis. The death of renal tubular epithelial cells (TECs) is an important pathophysiological process contributing to the development of nephrolithiasis.

[Significance of macrophage and cytokines in expression of stone matrix].

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(BACKGROUND). Urinary calculus consists of inorganic substances as a major component and organic substances as a minor component. In this study, the organic substances playing an important role in the formation of calculus, such as osteopontin, calprotectin, macrophage and cytokines, are

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