Twelve subjects will be prescribed a standard clinical dose of spironolactone of 1 mg/kg/day. The spironolactone will be provided as suspension.

Twelve subjects will be prescribed a standard clinical dose of prednisolone of 0.75 mg/kg/day or weekend dosing of 5 mg/kg/day as per sites standard of care. The prednisolone will be provided will be provided as suspension.

Muscular Dystrophy, Duchenne

Spironolactone will be prescribed for 6 months, after which the family and primary care physician will determine to either remain on spironolactone or transfer to prednisolone.

Spironolactone

Prednisolone will be prescribed for 6 months as the clinical standard of care.

Prednisolone

Nationwide Children's Hospital

Spironolactone Versus Prednisolone in DMD

A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD

The determination of whether spironolactone has similar efficacy to glucocorticoids in improving muscle strength in steroid naïve DMD patients. This will be determined by measuring the time to complete a 100 meter timed test (100M).

Electrolytes (Sodium, Potassium, Cloride and Carbon dioxide, mmol/L) will be measured on a monthly basis following initiation of either spironolactone or prednisolone.

Secondary outcome measures will be Dynamometry score, which is a summation of maximum voluntary isometric contraction test values for knee flexion, knee extension, elbow flexion, and elbow extension; 4-stair climb; North Star Ambulatory Assessment (NSAA); and time to arise from the floor.

Kevin Flanigan

Professor of Neurology

Muscular Dystrophy Association

Subjects will be randomly assigned to either to the spironolactone treatment group or to the standard clinical dose of corticosteroids.

Placebo capsules equal to those in the study drug, will be administered every 24 hours for the first 5 days after entry into the critical care unit

capsules of spironolactone 25 mg equal to placebo, will be given every 24 hours for the first 5 days after entry to the critical care unit

Acute Kidney Injury

A dose of 25 mg of spironolactone will be administered orally or through the nasogastric /nasoenteral tube to the patients every 24 hours, at 8-9 am.

Spironolactone 25 mg

The contents of a placebo capsule will be administered orally or through the nasogastric / nasoenteral tube to the patients every 24 hours, at 8-9 am.

Placebo oral capsule

Spironolactone on Acute Kidney Injury in Critically Ill Patients

Usefulness of Spironolactone for the Prevention of Acute Kidney Injury in Critically Ill Patients With Invasive Mechanical Ventilation

determine the concentrations of NGAL, KIM-1, oxidative stress and Hsp72 in urine

Norma Bobadilla

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

National Council of Science and Technology, Mexico

Universidad Nacional Autonoma de Mexico

Administer Eplerenone, 25 mg, orally twice daily for 4 weeks.

Administer a placebo tablet orally twice daily for 4 weeks

Hypertension

Dialysis

Hyperaldosteronism

Administer Eplerenone, 25 mg,orally twice daily for 4 weeks.

Eplerenone

Administer a placebo tablet orally twice daily for 4 weeks.

Placebo

Shaare Zedek Medical Center

Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?

Hypercholesterolemia

3,5-Diiodothyropropionic acid (DITPA) therapy

Johns Hopkins Bayview Medical Center

Study of 3,5-Diiodothyropropionic Acid (DITPA) in Hypercholesterolemic Patients

A Randomized, Double-Blind Placebo-Controlled Study of 3,5-diiodothyropropionic Acid (DITPA) in Combination With Standard Therapy to Attain NCEP ATP III Goal for LDL Cholesterol in Hypercholesterolemic Patients

gynecomastia/potasio

Spironolactone Versus Prednisolone in DMD

Spironolactone on Acute Kidney Injury in Critically Ill Patients

Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?

Study of 3,5-Diiodothyropropionic Acid (DITPA) in Hypercholesterolemic Patients

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