hypoglycin a/hipoglucemia

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Effect of hypoglycin A on insulin release.

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Thirty experimental and fifteen control Wistar rats were studied to determine whether hypoglycin A influences insulin levels in the body to contribute to the state of hypoglycemia usually observed in Jamaican vomiting sickness, a condition arising after ingestion of unripe ackees. This fruit also

Quantification of hypoglycin A and methylenecyclopropylglycine in human plasma by HPLC-MS/MS.

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Hypoglycin A (HGA) and methylenecyclopropylglycine (MCPG) are naturally-occurring amino acids known to cause hypoglycemia and encephalopathy. Exposure to one or both toxins through the ingestion of common soapberry (Sapindaceae) fruits are documented in illness outbreaks throughout the world.

Studies of the action of hypoglycin-A, an hypoglycaemic substance.

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Some biological effects of hypoglycin-A, a compound isolated from the fruit of Blighia sapida, have been investigated. Administration of this compound to animals caused drowsiness progressing to coma, and when large doses were given the animals died. For the rat, the oral and intraperitoneal LD50

Detection of toxic methylenecyclopropylglycine and hypoglycin A in litchi aril of three Chinese cultivars

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As a subtropical fruit with high commercial values, litchi is also a source of methylenecyclcopropylglycine (MCPG) and hypoglycin A (HGA), which could cause hypoglycemia and fatal encephalopathy in human. In this work, a quantitative method was developed well to detect MCPG and HGA present in litchi

Acute encephalopathy in children in Muzaffarpur, India: a review of aetiopathogenesis

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The acute encephalopathy occurring in children in Muzaffarpur, India, also recognised in other litchi-cultivating areas of India, Bangladesh, Vietnam and China, had previously been linked to litchi consumption. Recently, it has been identified as hypoglycaemic encephalopathy of an unusual aetiology

Hypoglycin stimulates insulin secretion.

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Hypoglycin A(0.01--1.0 mmol/l) stimulated insulin release from pieces of rabbit pancreas in vitro in the presence or absence of extracellular glucose. The relevance of this finding to the hypoglycaemia of Jamaican vomiting sickness is discussed.

Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study.

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Outbreaks of unexplained illness frequently remain under-investigated. In India, outbreaks of an acute neurological illness with high mortality among children occur annually in Muzaffarpur, the country's largest litchi cultivation region. In 2014, we aimed to investigate the cause and risk factors

Blighia sapida K.D. Koenig: A review on its phytochemistry, pharmacological and nutritional properties.

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Ackee plant (Blighia sapida K. D. Koenig) (Sapindaceae) is used in Sub-Saharan Africa (where it has its origin) and in different parts of the world (The Caribbean, North and South America, Europe). Traditionally it is used to manage numerous ailments like backache, constipation,

Mechanism of hypoglycaemic action of methylenecyclopropylglycine.

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The effects of methylenecyclopropylglycine (MCPG), the lower homologue of hypoglycin A, on starved rats are described. Upon oral ingestion of MCPG (43 mg/kg), a 50% decrease in blood glucose compared with controls was observed after 4 h. The plasma concentrations of lactate and non-esterified fatty

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