Obesity

D-allulose (psicose), a C-3 epimer of D-fructose, is defined one of the rare sugars since it is rarely found in nature. Rare sugars are monosaccharides which present in small quantities in commercial mixtures of D-glucose and D-fructose obtained from hydrolysis of sucrose or isomerization of D-glucose (5). D-allulose (psicose) has been demonstrated to be a non-calorie monosaccharide which has approximately 70% sweetness of sucrose. Various physiological activities of D-allulose (psicose) have been revealed. Of those, its glucose suppressive effect has been proven by both animal and clinical studies.

D-allulose

erythritol

Faculty of Medicine, Chiang Mai University

Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects

The Efficacy of D-allulose (Psicose) on Weight and Fat Loss and Insulin Resistance by a Randomized Double-blind, Parallel-group Study in Non-diabetic Obese Subjects

Supawan Buranapin

Assisstant professor

Chiang Mai University

Kagawa University

Patients with type 2 diabetes Interventions: processed meat hamburger and vegan sandwich

Obese subjects without diabetes Interventions: processed meat hamburger and vegan sandwich

Healthy lean controls Interventions: processed meat hamburger and vegan sandwich

Type 2 Diabetes

MacMuffin Fresh 300 ml Cafe Latte + 21 g sugar Energy: 513.6 kcal Carbohydrates 55g (44.8%) Proteins 20.5g (16.7%) Lipids 22 g (38.6%)

Processed meat hamburger

Burger with tofu + 300 ml green tea Energy 514.9 kcal Carbohydrates 54.2 g (44%) Proteins 19.9 g (16.2%) Lipids 22.8 g (39.8%)

Vegan sandwich

Institute for Clinical and Experimental Medicine

Processed Meat and Brain Regions Related to Reward and Addiction

Effects of Processed Meat on Brain Regions Related to Reward and Craving in Patients With Type 2 Diabetes, Obese Subjects and Healthy Controls

fMRI (functional magnetic resonance imaging) of the brain pre- and postprandially simultaneously with both meal tests with the use of the modern method of arterial spin labeling (ASL) which allows quantification of the blood perfusion of the brain regions involved in craving and reward.

Plasma concentrations of selected gut hormones will be measured enzymatically using standard kits

Plasma concentrations of selected oxidative stress markers will be measured enzymatically using standard kits

Hana Kahleova

MD, PhD

We will flush the deceased donor kidney with UW (perfusion solution) + sodium thiosulfate (STS)

Kidney will be flushed with UW (perfusion solution) which is the normal standard of care.

End Stage Renal Disease (ESRD)

The kidney will have 100 mL of 500µM STS added directly to the existing pulsatile perfusion solution at 4°C.

Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25%

London Health Sciences Centre, University Hospital

Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation

between 1 week and 1 year following transplant

Measuring death of tubular epithelial cells that form the renal tubules of the kidneys.

Patient Urine protein/creatinine ratio results

Patient urinary injury biomarkers (KIM-1/NGAL).

Alp Sener

Principal Investigator

Lawson Health Research Institute

For the purposes of this study we will flush the deceased donor kidney with UW (perfusion solution) or UW + sodium thiosulfate (STS). There will be two groups in the study - UW with or without STS and patients will be randomly assigned to a group in a 1:1 ratio (i.e. 50 in one group and 50 in the other).

iris/obesidad

Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects

Processed Meat and Brain Regions Related to Reward and Addiction

Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation

Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions

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