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isopsoralen/psoralea
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Micellar electrokinetic capillary chromatography of psoralen and isopsoralen.
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In this paper, a micellar electrokinetic capillary chromatography (MEKC) method to analyze the active components of psoralen and isopsoralen in the Chinese herb Psoralea corylifolia L. was developed. It was found that the optimum separation condition for the analysis of these compounds was a buffer
Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats.
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BACKGROUND
Modern studies have shown that psoralen has a significant inhibitory effect on tumor growth in a variety of animals and humans.
OBJECTIVE
To obtain coumarin compounds - psoralen and isopsoralen - from traditional Chinese medicine Psoralea corylifolia L. using chromatographic techniques
[A study on nasal absorption of psoralen and isopsoralen in Psoralea corylifolia L].
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OBJECTIVE
To investigate the nasal absorption regularities of psoralen and isopsoralen of different concentrations.
METHODS
Building an experimental model of rat in situ nasal recirculation and determining the contents of psoralen and isopsoralen by HPLC.
RESULTS
The nasal absorption of psoralen and
Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders.
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Psoralen and isopsoralen, furocoumarins isolated from the plant Psoralea corylifolia L., were demonstrated to exhibit in vitro inhibitory actions on monoamine oxidase (MAO) activities in rat brain mitochondria, preferentially inhibiting MAO-A activity over MAO-B activity. This inhibition of enzyme
Coordination Mechanism and Bio-Evidence: Reactive γ-Ketoenal Intermediated Hepatotoxicity of Psoralen and Isopsoralen Based on Computer Approach and Bioassay
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Psoralen and isopsoralen are secondary plant metabolites found in many fruits, vegetables, and medicinal herbs. Psoralen-containing plants (Psoralea corylifolia L.) have been reported to cause hepatotoxicity. Herein, we found that psoralen and isopsoralen were oxidized by CYP450s to reactive
Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.
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Isopsoralen (IPRN), one of the main effective ingredients in Psoralea corylifolia Linn, has a variety of biological effects, including antiosteoporotic effects. In vivo studies show that IPRN can increase bone strength and trabecular bone microstructure in a sex hormone deficiency-induced
[Effect of isopsoralen on the proliferation and differentiate of osteoblasts in vitro].
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OBJECTIVE
To investigate the effect of isopsoralen on proliferation, osteogenic differentiation and calcification capacity of rat calvarial osteoblasts (ROB).
METHODS
Segregated neonatal SD rat skull,and digestion with enzyme to obtain bone cells and cultured in MEM containing 10% FBS. Exchange the
[Effects of isopsoralen on bone marrow stromal stem cells differentiate and proliferate in vitro].
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OBJECTIVE
To investigated the effects of isopsoralen on bone marrow stromal stem cells (BMSCs) differentiate and proliferate in vitro.
METHODS
The stratum of mononuclear cells were separated and collected from the rat bone marrow sample by the all bone marrow cell culture methods. The cells were
[The influence of further processing on Psoralea corylifolia alcohol extracts and the content of psoralen and isopsoralen].
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OBJECTIVE
To improve the processing method of Psoralea corylifolia.
METHODS
The self-made processing machine was used to flatten Psoralea corylifolia. Then it was extracted with water soluble and alcohol soluble with Psoralea corylifolia unflatten as the amount of Psoralea corylifolia and the
[Determination of psoralen and isopsoralen in Psoralea corylifolia L. from different habitats].
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OBJECTIVE
To study the psoralen and isopsoralen content in Psoralea corylifolia from different habitats.
METHODS
C18 column was used. Mobile phase was methanol-water (45:55). The detection wavelength was at 245nm and the flow rate was 1.0 ml/min.
RESULTS
The linearity was obtained over the range of
[Selective isolation of isopsoralen from crude extract of Psoralea corylifolia. L by using inclusion method of host-guest molecules].
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OBJECTIVE
To isolate the chemical components from extracted crude of Psoralea corylifolia L.
METHODS
Applicate the function of molecular recognition in supramolecular chemistry, use 1,1,6,6-tetraphenylhexa-2,4-diyne-1,6-diol as the host molecule and chemical components in extracted crude of Psoralea
Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography.
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Psoralen and isopsoralen were separated from Psoralea corylifolia by high-speed counter-current chromatography (HSCCC). A two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (5:5:4.5:5.5, v/v) was used for HSCCC separation, and yielded, from 100 mg of crude extract, 39.6 mg of
[Rapid analysis of psoralen and isopsoralen in Psoralea corylifolia by microwave-assisted extraction].
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OBJECTIVE
To establish a convenient and rapid method of microwave-assisted extraction (MAE) for the extraction of psoralen and isopsoralen in Psoralea corylifolia.
METHODS
The effects of various parameters on the MAE were investigated with several single-factor tests, and compared with the
Evaluation of the influence of salt processing on pharmacokinetics of psoralen and isopsoralen in Psoralea corylifolia L.
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A sensitive, specific and rapid ultra-high-pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method has been developed to investigate pharmacokinetic properties of psoralen and isopsoralen, two compounds isolated from raw/salt-processed fruit of Psoralea corylifolia L.
Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds.
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Psoralea corylifolia L. (Fabaceae) is a widely used medical plant in China. This study was designed to screen and identify bioactive compounds with anticancer activity from the seeds of Psoralea corylifolia L. One volatile fraction (fraction I) and three other fractions (fraction II, III, IV) from
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