opc/accidente cerebrovascular

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Antidepressant Effects of Aripiprazole Augmentation for Cilostazol-Treated Mice Exposed to Chronic Mild Stress after Ischemic Stroke.

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The aim of this study was to determine the effects and underlying mechanism of aripiprazole (APZ) augmentation for cilostazol (CLS)-treated post-ischemic stroke mice that were exposed to chronic mild stress (CMS). Compared to treatment with either APZ or CLS alone, the combined treatment resulted in

Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole.

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We investigated the question of whether an animal model of post-stroke depression in ischemic stroke can be developed by additional chronic mild stress (CMS) procedures. Behavioral and histopathological analysis was performed for examination of the depressive disorders in CMS, left middle cerebral

Fatal stroke with aripiprazole.

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Atrial Fibrillation and Injected Aripiprazole: A Case Report.

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Background: Aripiprazole is a widely clinically employed antipsychotic drug for a range of indications. It has unusual pharmacodynamics as a dopamine D2 receptor partial-agonist with complex interactions with serotonin receptors and, a relatively unusual long elimination half-life. Although other

Role of dopamine on functional recovery in the contralateral hemisphere after focal stroke in the somatosensory cortex.

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Functional recovery after a stroke is important for patients' quality of life. Not only medical care during the acute phase, but also rehabilitation during the chronic phase after a stroke is important. However, the mechanisms underlying functional recovery, particularly the chronic phase after

Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia.

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Previous studies have demonstrated that aripiprazole (APZ), a third-generation atypical antipsychotic drug, exhibits anti-depressant and neuroprotective effects by promoting dopaminergic neuronal cell recovery in stroke. To investigate the neuroprotective effects of APZ, behavioral and

Torsades de pointes after administration of low-dose aripiprazole.

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OBJECTIVE To describe a case of torsades de pointes (TdP) in a patient treated with aripiprazole. METHODS A 42-year-old white male with schizophrenia, diabetes, hypertension, and a history of stroke was admitted to the intensive care unit following 2 days of fever, diarrhea, and altered mental

Aripiprazole in the treatment of Alzheimer's disease.

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BACKGROUND Psychosis is a common and difficult to treat symptom in Alzheimer's disease (AD). It is a cause of diminished quality of life and caregiver distress. Atypical antipsychotics are frequently used for the treatment of dementia-related psychosis, despite FDA warnings because of increased

Effects of switching from olanzapine, quetiapine, and risperidone to aripiprazole on 10-year coronary heart disease risk and metabolic syndrome status: results from a randomized controlled trial.

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OBJECTIVE This study examined the clinical significance of switching from olanzapine, quetiapine, or risperidone to aripiprazole by examining changes in predicted risk of cardiovascular disease (CVD) according to the Framingham Risk Score (FRS) and metabolic syndrome status. FRS estimates 10-year

Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.

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Poststroke depression (PSD), which occurs in approximately one-third of stroke survivors, is clinically important because of its association with slow functional recovery and increased mortality. In addition, the underlying pathophysiological mechanisms are still poorly

Two cases of emotional disorder after middle cerebral artery infarction showing distinct responses to antidepressant treatment.

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Many emotional disturbances such as post-stroke depression (PSD) and emotional incontinence (EI) commonly occur following cerebrovascular events. The efficacy of antidepressants for these conditions has been established but their comorbid treatment has not been well characterized. In the current

Incidence of cardiovascular outcomes and diabetes mellitus among users of second-generation antipsychotics.

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OBJECTIVE To examine the risk of cardiovascular outcomes and diabetes mellitus in patients prescribed second-generation antipsychotics. METHODS From the MarketScan claims database, nondiabetic adults prescribed aripiprazole between July 2003 and March 2010 were propensity score-matched with patients

Cerebro- and cardiovascular conditions in adults with schizophrenia treated with antipsychotic medications.

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OBJECTIVE To report on the relative risk of cerebro- and cardiovascular disorders associated with antipsychotic treatment among adults with schizophrenia. METHODS Medical and pharmacy claims data from the South Carolina Medicaid program were extracted to compare the prevalence rates for four coded

Summary of the comparative effectiveness review on off-label use of atypical antipsychotics.

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BACKGROUND Conventional and atypical antipsychotic medications are approved by the FDA for treatment of schizophrenia and bipolar disorder. Over many decades, the widespread use of conventional antipsychotics produced various side effects requiring additional medications, such as the atypical

Cost-effectiveness of asenapine in the treatment of schizophrenia in Canada.

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OBJECTIVE Asenapine is the first tetracyclic antipsychotic approved in Canada for the treatment of schizophrenia (SCZ). Asenapine has shown a comparable efficacy profile to other atypical antipsychotics and it is associated with a favourable metabolic profile and less weight gain. This study aimed

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