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paris/antineoplásico
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Substituting one Paris for another? In vitro cytotoxic and in vivo antitumor activities of Paris forrestii, a substitute of Paris polyphylla var. yunnanensis.
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BACKGROUND
Chong-lou (Paris polyphylla var. yunnanensis or P. polyphylla var. chinensis) is traditionally used as an anticancer medicine in China. It is also the material basis of some Chinese patent anticancer medicines, such as Gan-Fu-Le capsules, Bo-Er-Ning capsules, Lou-Lian capsules, Ruan-Jian
[Anti-tumor constituents from Paris polyphylla var. yunnanensis].
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OBJECTIVE
To study the anti-tumor active constituents from the rhizome of Paris polyphylla var. yunnanensis.
METHODS
The compounds were isolated by column chromatography with silica gel, and purified by Sephadex LH-20 columu chromafography and reverse-phase preparative, HPLC. The structures were
[Neurosurgical multicenter study of cerebral metastases (Neurosurgical departments of Paris Beaujon, Paris Sainte-Anne, Strasbourg)].
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We report a multicentric outcome study of cerebral metastases in 174 patients collected consecutively in three neurosurgical centers in France. Age and condition of patients allowed surgical operation; the sex ratio was 1.67. The revelation mode was usual. However tumoral hemorrhage frequency was
Paris polyphylla: chemical and biological prospectives.
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Paris polyphylla J.E. Smith is extensively used in traditional systems of Indian and Chinese medicines mainly for its anticancerous property. The national and international demand for P. polyphylla is constantly increasing and most of the supplies come from wild. Illegal and unscientific
[Dose intensity in anticancer chemotherapy. Paris, 19 December 1994].
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Chemical characteristics of saponins from Paris fargesii var. brevipetala and cytotoxic activity of its main ingredient, paris saponin H.
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More attention was paid to the anti-tumor activity of Rhizoma Paridis (RP) recently, of which the wild resource was decreased significantly. This study was aimed to elucidate the chemical characteristics of Paris fargesii var. brevipetala (PFB) that may be administrated as alternate resource of
Anti-neoplastic property of a crude extract from Paris formosana.
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Chemical constituents and antitumor activity from Paris polyphylla Smith var. yunnanensis.
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Eleven compounds were isolated from the rhizomes of Paris polyphylla Smith var. yunnanensis. Their structures were elucidated on the basis of rigorous 1D and 2D NMR experiments as well as comparison with the literature data. To the best of our knowledge, compound 1 was only predicted by UPLC/Q-TOF
Anti-cancer treatment - 12th International Congress. 4-7 February 2002, Paris, France.
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The 12th International Congress on Anti-Cancer Treatment (ICACT), endorsed by the American Society of Clinical Oncology, was held in Paris, France. Led by Gabriel Hortbagyi (MD Anderson Cancer Center, USA) and David Khayat (Hopital de la Pitie Salpetriere, France), the meeting was well organized and
Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats.
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Polyphyllin D and Paris H are two potential antitumor active components in Paris polyphylla, one of the Traditional Chinese Medicines (TCMs). The present study details the development and validation of a rapid, sensitive and accurate LC-ESI-MS/MS method for the separation and simultaneous
Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays.
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Paris saponins, also known as polyphyllins, are natural compounds extracted from Paris polyphylla, which have many pharmacological activities, such as anti-inflammation and anti-cancer. In particular, paris saponin I, II, VII and polyphyllin VI are the components of the quality standard for Paris
[IX. International Congress on cancer treatment. 2-5 February 1999, Paris, France].
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[Separation and identification of active constituents of Paris vietnamensis].
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OBJECTIVE
To study the anti-tumor bioactive steroid saponins of Paris vietnamensis (Takht.).
METHODS
The constituents were isolated and purified by chromatography and their structures were identified by spectral analysis and physicochemical properties. The cytotoxic bioactivities of the constituents
Effect of Paris saponin on antitumor and immune function in U14 tumor-bearing mice.
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We evaluated the effect of Paris saponin on inhibition of cervical cancer in mice and on immune regulation in tumor-bearing mice. MTT assay was used to examine the effect of Paris saponin on U14 cell proliferatiosn in vitro; the ascites tumor model of U14 cervical cancer was established to observe
Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells.
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OBJECTIVE
To investigate the synergistic mechanisms of Paris Saponin II (PSII) and Curcumin (CUR) in lung cancer.
METHODS
The combination changed the cellular uptake of CUR and PSII, apoptosis, cell cycle arrest and cytokine levels were analysed on different lung cancer cells.
RESULTS
The
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