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The Inflammatory Process and the Medical Imaging in Patients With an Inflammatory Disease of the Central Nervous System.

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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system affecting 60.000 persons in France and characterized by widespread inflammation, focal demyelination, and a variable degree of axonal loss. In recent years the concept of MS as an inflammatory neurodegenerative

Imaging of Intracerebral Inflammation in MS

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Study design This study is a prospective cross-sectional controlled multicentric clinical study in 45 MS patients and 20 controls. Four groups of person will be included and compared: - Group I: 20 healthy volunteers aging from 18 to 65 years. These healthy volunteers will be matched for age and sex

Nutritional Status and Body Composition in Childhood Inflammatory Bowel Disease

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Patients 6 to 18 years of age at the time of enrolment who have IBD at any stage of disease activity, on any or no treatment and age- and sex-matched healthy controls will be included. All participants will be followed for 1 year. Written informed consent will be obtained from the parents or

Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases

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Protocol: TRANSREG is a multicentric, uncontrolled, open-label study, comparing biological and clinical responses to the administration of low doses IL2 across 14 selected pathologies: rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, psoriasis, Behcet's disease, Wegener's

Central and Systemic Inflammation in Alzheimer's Disease

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Introduction: Alzheimer's disease (AD) is characterized by abnormal β-amyloid deposition associated with Tau-based neurofibrillary tangles. The metabolism of these proteins is modulated by the individuals physiological background. In addition to genetic factors, early brain inflammation and the

Male Infertility Related With Post Infection Inflammatory Syndrome

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Progress of research. Timeframe Search - Duration of inclusions: 30 months - Duration of patient follow-up: 7 months - Total duration of the study: 37 months Within the framework of their coverage in AMP, the barren couples have a consultation with the doctors of the reproduction and one with the

The Value of I-Scan and Confocal Laser Endomicroscopy for the Assessment of Chronic Inflammatory Bowel Disease

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The value of I-Scan and Confocal Laser Endomicroscopy for the assessment of chronic inflammatory bowel disease Background Colonoscopy plays an important role in the diagnosis, assessment of activity, extension and response to therapy in chronic inflammatory bowel disease (IBD). Conventional

Estimating Indirect and OOP Costs in Pediatric Inflammatory Bowel Disease: a National Study

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Specific objectives: 1. Determine the Indirect and out of pocket costs of care of children with IBD, incurred by caregivers, funders, and the health system. Costs include: 1. Indirect costs - all costs related to the patient having the disease but not related to direct health care costs. These

Immunological Consequences of CARD15/NOD2 Mutations in Crohn's Disease

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Crohn's Disease (CD) affects about 60.000 to 80.000 people in France. It is characterised by a chronic or relapsing inflammation of the gut. Its aetiology is largely unknown, limiting the development of preventive and curative therapeutic options. In 2001, we have identified the first CD

Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms

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In December 2019, China reported the first cluster of severe acute respiratory syndrome due to a new coronavirus (SARS-CoV-2). The disease rapidly spread into a global pandemic of public health emergency worldwide leading to more than 330.000 deaths (data from May 25th, 2020). We have, to date, no

Pharmacokinetics of Prednisone in Adults

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OBJECTIVES Main objective Describe the pharmacokinetic of prednisone when administered to adult patients in the setting of an internal medicine service. Secondary objectives To identify individual vulnerability factors (renal and hepatic functions, albuminemia, age, comedications) and glucocorticoid

Place of Circulating Biomarkers and Respiratory Eicosanoids in the Prognosis of Severe Forms of Covid-19 Pneumonia

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The reason for the involvement of overweight in the severity of viral respiratory pathologies, particularly during influenza and coronavirus infections, has been the subject of numerous studies which have made it possible to objectify the importance of viral load (at least in mice), particularly in

Hidradenitis Suppurativa and Periodontal Diseases

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The principal hypothesis of this project is the existence of an association between Hidradenitis suppurativa (HS) and periodontal diseases (PD). The primary objective is to evaluate this association using a multicenter cross-sectional clinical approach. The secondary objectives are: - To study the

Pediatric Penetrating Crohn's Disease

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This study is cross-sectional and is carrying out between 1995 and 2017 in two French tertiary referral centers (Montpellier, Toulouse) and EPIMAD registry which is currently the largest Inflammatory Bowel Disease cohort in world and cover 9.6% of French population (Nord, Pas-de-Calais, Somme, and

Impaired Secretory IgA and Mucosal Immunity in Cystic Fibrosis

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Impaired secretory IgA and mucosal immunity in cystic fibrosis: role of CFTR-related epithelial changes in the regulation of pIgR-mediated IgA transcytosis and contribution to lung pathology and impaired defence against bacterial infections. PROJECT DESCRIPTION Cystic fibrosis (CF) represents the

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