The participants who will have Multi-Carotenoids for 8 weeks The intervention is Multi-Carotenoids 30 mg for 8 weeks.

Significant Prostate Cancer

Urine Metabolomics

Cancer Screening

All participants in the second stage will receive multi-carotenoids 30 mg qd for 8 weeks.

Multi-Carotenoids

Department of Urology, National Taiwan University Hospital

Decipher Lethal Prostate Cancer Biology - Urine Metabolomics

Decipher the Biology of Lethal Prostate Cancer - Urine Metabolomics Profiling in Men Receiving Prostate Biopsy and Men With Diagnosed Prostate Cancer Receiving MCS Supplementation

Observe the change of metabolomics in urine samples collected before and upon the completeness of MCS supplementation

National Taiwan University Hospital

A total of 600 male patients who are planning to have prostate biopsy will be enrolled in the first stage of this study for measuring urine metabolomics. Only the patients who have non-metastatic significant prostate cancer, insignificant prostate cancer, ASAP/PIN, or benign prostate proved by prostate biopsy are enrolled into the second stage in which MCS supplementation will be used for 8 weeks.
In addition, 20 men and 20 women will be enrolled as a healthy control without any further medication.

Patients will consume two 5.5 oz. cans of tangerine tomato juice every day until their scheduled surgery. (approximately 4 weeks)

Patients consume two cans of red tomato juice daily until their scheduled surgery (approximately 4 weeks).

Stage I Prostate Cancer

Stage IIA Prostate Cancer

Stage IIB Prostate Cancer

Stage III Prostate Cancer

Stage IV Prostate Cancer

Group II will consume two 5.5 oz. cans of tangerine tomato juice every day until their scheduled surgery. (approximately 4 weeks).

dietary intervention (tangerine tomato juice)

Group III will consume two 5.5 oz. cans of red tomato juice every day until their scheduled surgery (approximately 4 weeks).red tomato juice

dietary intervention (red tomato juice)

Men enrolled in the study will be asked to complete a 3-Day Food Record and a series of additional questionnaires (urologic symptom and quality of life questionnaire) at home.

questionnaire administration

Blood and urine samples at enrollment and blood, urine, and prostate tissue at the time of surgery to determine compliance with the intervention product and tomato phytochemical biodistribution. Additionally, we will correlate each type of tomato juice with lycopene presence in plasma, urine, and tissue provided by subjects on the day of surgery.

Correlative studies

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center

OhioHealth Dublin Methodist Hospital

Tangerine or Red Tomato Juice in Treating Patients With Prostate Cancer Undergoing Surgery

A Comparison of Tangerine and Red Tomato Juice in Men With Prostate Cancer: A Pilot Study

Linear regression analysis will be used to examine differences in carotenoid levels of biological samples between groups.

Compared via 3 way analysis of variance (ANOVA) with pairwise comparisons or nonparametric Kruskal-Wallis tests where appropriate.

Compared via 3 way ANOVA with pairwise comparisons, or nonparametric Kruskal-Wallis tests where appropriate.

phytoene/cáncer

Decipher Lethal Prostate Cancer Biology - Urine Metabolomics

Tangerine or Red Tomato Juice in Treating Patients With Prostate Cancer Undergoing Surgery

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