The present invention is directed towards a method of modulation of the innate immune of an organism system with the phosphorylated polyprenols of the present invention. The present invention is also directed towards a method of activation and/or modulation of the Toll-like Receptors with the phosphorylated polyprenols of the present invention. The present invention is also directed towards compound(s) comprising C35-C90 polyisoprenyls of Formula 1 and Formula 2 and their derivatives as well as methods of use of including activation and/or modulation of TLRs including TLR-2 and TLR-4 receptors and uses thereof including, e.g., use as antimicrobial, immunoregulatory, anti-cancer, for control of inflammatory conditions and as vaccine adjuvants.

Kuritz; Tanya

Methods and compositions for modulation of innate immunity

The invention provides composition comprising, 1) polyprenol monophosphates of the formula H--[--CH2-C(CH3).dbd.CH--CH2]n-O--P(.dbd.O)(OH)2 wherein n is an integer from 6-19 inclusive or a salt thereof, and 2) polyprenol pyrophosphates of the formula H--[--CH2-C(CH3).dbd.CH--CH.sub.2 ].sub.m --O--P(.dbd.O)(OH)--O--P(.dbd.O)(OH).sub.2 wherein m is an integer from 6-19 inclusive or a salt thereof, which is useful as an antiviral agent, as an immunomodulatory agent, and for treating cancer. The invention also provides pharmaceutical compositions comprising the compositions of the invention as well as therapeutic methods for using the the compositions.

polyprenol/cáncer

Methods and compositions for modulation of innate immunity

Therapeutic composition and methods

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