pteridium aquilinum/cáncer

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Bracken-fern extracts induce cell cycle arrest and apoptosis in certain cancer cell lines.

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Bracken fern [Pteridium aquilinem (L.) kuhn (Dennstaedtiaceae)] is one of the most common species on the planet. It has been consumed by humans and animals for centuries. Use by some human groups is because they believe bracken fern is good for health as plant medicine. However, it is also one of

Possible association between gastric cancer and bracken fern in Venezuela: an epidemiologic study.

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To explore a possible connection between specific environmental factors that might explain the high rates of stomach cancer in people living in the highlands of western Venezuela, an epidemiologic study was conducted in 2 regions of contrasting topography. The regions embrace 3 Andean states,

Gastric cancer in Gwynedd. Possible links with bracken.

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One hundred and one histologically confirmed gastric cancer patients in Gwynedd, North Wales, were matched by sex, age and social class to two hospital inpatients without cancer. Seventy-seven of the gastric cancer cases were also matched, using the same criteria, to a patient with a confirmed

Enhancement by bracken of induction of tumours of the upper alimentary tract by N-propyl-N-nitrosourethan.

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The effect of bracken on the induction of tumours of the upper alimentary tract by N-propyl-N-nitrosourethan (PNU) was studied in 7-week-old ACI rats. Group I received a solution of 400 pts/10(6) of PNU in their drinking water for 6 weeks; Groups II and III were given PNU as in Group I, and then

Induction of mammary cancer in CD rats fed bracken diet.

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Fifteen male and 15 female Charles River Sprague-Dawley rats (CD rats) of 6 weeks old were given a diet containing 30% bracken fronds throughout the experimental period of 260 days. Male rats fed bracken diet developed multiple ileal tumors and urinary bladder tumors with incidences of 100% and 60%,

Alpha-ecdysone, a new bracken fern factor responsible for neoplasm induction in the Egyptian toad (Bufo regularis).

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Neoplastic lesions were induced in 10 out of 58 experimental toads (Bufo regularis) force-fed with alpha-ecdysone, which naturally occurs in the leaves of bracken fern (Pteris aquilina). The results of this study prove that alpha-ecdysone may be one of the factors responsible for the carcinogenicity

Induction of tumors of the urinary bladder in female mice following surgical implantation of glass beads and feeding of bracken fern.

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The carcinogenic effect of bracken fern (Pteris aquilina) to the urinary bladder of mice was studied. Powdered bracken fern mixed with a basic commercial diet (1:4 by weight) was fed to a group of 40 ICR strain mice for 20 weeks after the implantation of a glass bead into the bladder. A total

Induction of tumors in rats by bracken fern (Pteridium aquilinum) from Ouro Preto (Minas Gerais, Brazil).

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1. The possible carcinogenicity of bracken fern (Pteridium aquilinum, common name: "Broto de Samambaia") which is used as food by the population of Ouro Preto (Minas Gerais, Brazil) and neighboring areas, was studied in rats. 2. Fifteen (6 female and 9 male) 45-day old Wistar rats were fed a diet

Bracken as a risk factor in digestive tract tumors: state of the art.

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The present knowledge of the risks of exposure to bracken fern (Pteridium aquilinum) is presented. The history of research on bracken toxicity is reviewed, covering the animal observations and chemical analysis, and focusing on the carcinogenic effects in various animal species and on the nature and

Tumor induction in germ-free rats fed bracken (Pteridium aquilinum).

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This study indicated that there was no significant difference in the incidence of intestinal tumors between germ-free and conventional rats fed a diet containing bracken, suggesting that gut microflora did not play a definite role in bracken tumorigenesis. However, bracken induced exclusively

Histogenesis of urinary bladder cancer induced in rats by bracken fern.

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Histologic examination of the urinary bladders of albino rats fed bracken fern (Pteris aqulinum) showed epithelial hyperplasia in all test animals after 3 weeks of feeding and nuclear abnormalities at 4 to 6 weeks. Epithelial tumors were present in animals surviving more than 12 weeks, and invasion

Induction of tumors in ACI rats given a diet containing ptaquiloside, a bracken carcinogen.

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Fifteen female ACI rats initially 5 weeks old were each given a diet containing 0.027-0.08% ptaquiloside [(PT) CAS: 87625-62-5], a carcinogen in bracken, throughout the 210-day experimental period. A control group of 20 female ACI rats was given basal diet without PT. Both ileal and urinary bladder

Human gastric cancer, Helicobacter pylori and bracken carcinogens: A connecting hypothesis.

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Long term infection of Helicobacter pylori (Hp) virulent strains is a key factor in the genesis of human gastric cancer, and so are certain dietary proinflammatory and genotoxic compounds. Carcinogenic bracken fern (Pteridium spp.) is one of these. Toxins from this plant are consumed as bracken

Bracken fern, phenacetin, and cancer of the urinary tract.

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Bracken fern, a forage contaminant, is causally related to urinary bladder cancer in animals. In this review of experimental studies on carcinogenesis of bracken fern, little evidence of an association between cancer and bracken fern in humans was observed. Clinicoepidemiological studies have shown

Bracken fern-induced malignant tumors in rats: absence of mutations in p53, H-ras and K-ras and no microsatellite instability.

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Bracken fern (genus Pteridium) has been shown to induce tumors in domestic and experimental animals. Epidemiological studies have also shown an association between human exposure to bracken toxins and increased risk for the development of upper gastrointestinal tract tumors. Our aim in this study

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