12 resultados
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the production and use of a family of purpurins, a family of chlorins and metal complexes of the purpurins and chlorins, and to purpurin- and chlorin-containing compositions. The purpurins have a reduced pyrrole ring and
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the production and use of a family of purpurins, a family of chlorins and metal complexes of the purpurins and chlorins, and to purpurin- and chlorin-containing compositions. The purpurins have a reduced pyrrole ring and
BACKGROUND
Cancer causes a substantial portion of all human deaths. Many cancers, such as lung cancer, continue to be resistant to known chemotherapy regiments; thus, there is a need to identify improved treatment methods.
Emerging evidence indicates that impaired cellular metabolism is the defining
BACKGROUND OF THE INVENTION
The detection of early neoplastic changes is important from an outcome point of view because once invasive carcinoma and metastasis have occurred, treatment is difficult. At present, excisional biopsy followed by histology is considered the "gold standard" for diagnosis
BACKGROUND OF THE INVENTION
This invention relates to treatment and diagnosis of cancer through the use of IR imaging and photodynamic therapy employing porphyrin related compounds and more particularly certain analogs of chlorins and bacteriochlorins.
Photosensitizers are chemicals which kill cells
FIELD OF THE INVENTION
This invention relates to the production and use of imines of porphyrins, of porphyrins, and of related compounds, including metal complexes, e.g., benzochlorinimines and benzochlorinimine metal complexes, which are useful in photodynamic therapy. The invention also relates to
BACKGROUND OF THE INVENTION
A major challenge of cancer therapy is preferential destruction of malignant cells with sparing of the normal tissue. Critical for successful eradication of malignant disease are early detection and selective ablation of the malignancy. This proposal addresses both
BACKGROUND OF THE INVENTION
A major challenge of cancer therapy is preferential destruction of malignant cells with sparing of the normal tissue. Critical for successful eradication of malignant disease are early detection and selective ablation of the malignancy. This proposal addresses both
DESCRIPTION
The invention concerns the sphere of medicine, particularly the sphere of photodynamic therapy (PDT) with the use of biologically active compounds.
Photosensitizers (PS) are used as therapeutic agents at PDT and as fluorescent labels at photodynamic diagnostics (PDD).
Mono-L-aspartil
The invention concerns the sphere of medicine, particularly the sphere of photodynamic therapy (PDT) with the use of biologically active compounds.
Photosensitizers (PS) are used as therapeutic agents at PDT and as fluorescent labels at photodynamic diagnostics (PDD).
Mono-L-aspartil chlorin e.sub.6
FIELD OF THE INVENTION
This invention relates to the production and use of imines of porphyrins, of porphyrins, and of related compounds, including metal complexes, e.g., benzochlorinimines and benzochlorinimine metal complexes, which are useful in photodynamic therapy. The invention also relates to
BACKGROUND OF THE INVENTION
Photodynamic therapy (PDT), now a well recognized treatment for the destruction of tumors, utilizes the ability of a selectively retained photosensitizer to elicit an efficient photodynamic reaction upon activation with tissue penetrating light Pandey, R., Zheng, G.