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12 resultados
Use of purpurins, chlorins and purpurin- and chlorin-containing compositions
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the production and use of a family of purpurins, a family of chlorins and metal complexes of the purpurins and chlorins, and to purpurin- and chlorin-containing compositions. The purpurins have a reduced pyrrole ring and
Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the production and use of a family of purpurins, a family of chlorins and metal complexes of the purpurins and chlorins, and to purpurin- and chlorin-containing compositions. The purpurins have a reduced pyrrole ring and
Glutamate dehydrogenase 1 inhibitors and methods of treating cancer
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BACKGROUND
Cancer causes a substantial portion of all human deaths. Many cancers, such as lung cancer, continue to be resistant to known chemotherapy regiments; thus, there is a need to identify improved treatment methods.
Emerging evidence indicates that impaired cellular metabolism is the defining
Adduct of fluorescent dye and tumor avid tetrapyrrole
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BACKGROUND OF THE INVENTION
The detection of early neoplastic changes is important from an outcome point of view because once invasive carcinoma and metastasis have occurred, treatment is difficult. At present, excisional biopsy followed by histology is considered the "gold standard" for diagnosis
Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
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BACKGROUND OF THE INVENTION
This invention relates to treatment and diagnosis of cancer through the use of IR imaging and photodynamic therapy employing porphyrin related compounds and more particularly certain analogs of chlorins and bacteriochlorins.
Photosensitizers are chemicals which kill cells
Method of treating cancer tumors with imine porphyrin compounds
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FIELD OF THE INVENTION
This invention relates to the production and use of imines of porphyrins, of porphyrins, and of related compounds, including metal complexes, e.g., benzochlorinimines and benzochlorinimine metal complexes, which are useful in photodynamic therapy. The invention also relates to
Metallation enhancements in tumor-imaging and PDT therapy
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BACKGROUND OF THE INVENTION
A major challenge of cancer therapy is preferential destruction of malignant cells with sparing of the normal tissue. Critical for successful eradication of malignant disease are early detection and selective ablation of the malignancy. This proposal addresses both
Metallation enhancements in tumor-imaging and PDT therapy
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BACKGROUND OF THE INVENTION
A major challenge of cancer therapy is preferential destruction of malignant cells with sparing of the normal tissue. Critical for successful eradication of malignant disease are early detection and selective ablation of the malignancy. This proposal addresses both
Photosensitizer and method for production thereof
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DESCRIPTION
The invention concerns the sphere of medicine, particularly the sphere of photodynamic therapy (PDT) with the use of biologically active compounds.
Photosensitizers (PS) are used as therapeutic agents at PDT and as fluorescent labels at photodynamic diagnostics (PDD).
Mono-L-aspartil
Photosensitizer and method for production thereof
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The invention concerns the sphere of medicine, particularly the sphere of photodynamic therapy (PDT) with the use of biologically active compounds.
Photosensitizers (PS) are used as therapeutic agents at PDT and as fluorescent labels at photodynamic diagnostics (PDD).
Mono-L-aspartil chlorin e.sub.6
Production and use of imines of porphyrins, of porphyrin derivatives and of related compounds, and of compositions containing such imines
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FIELD OF THE INVENTION
This invention relates to the production and use of imines of porphyrins, of porphyrins, and of related compounds, including metal complexes, e.g., benzochlorinimines and benzochlorinimine metal complexes, which are useful in photodynamic therapy. The invention also relates to
Galectin recognized photosensitizers for photodynamic therapy
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BACKGROUND OF THE INVENTION
Photodynamic therapy (PDT), now a well recognized treatment for the destruction of tumors, utilizes the ability of a selectively retained photosensitizer to elicit an efficient photodynamic reaction upon activation with tissue penetrating light Pandey, R., Zheng, G.
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