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5 resultados
Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating.
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Studies on the pathology of spinal cord injury (SCI) have focused on inflammation-associated neuronal apoptosis. The traditional Chinese medicine safranal has been studied extensively and found to have various beneficial health effects. However, study of its potential role in neuroprotection and the
Histopathological and behavioral evaluations of the effects of crocin, safranal and insulin on diabetic peripheral neuropathy in rats.
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OBJECTIVE
Crocin and safranal, the major constituents of saffron, exert neuroprotective effects. In the present study, we investigated the effects of crocin and safranal (alone or in combination with insulin) on peripheral neuropathy in diabetic rats.
METHODS
Diabetes was induced by intraperitoneal
Akt/GSK-3β/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia-reperfusion injury in rats.
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OBJECTIVE
Traditional medicine has been appropriately identified as the most productive soil for the cultivation and harvesting of modern medicines. Herein, we postulate that safranal, an active constituent of Crocus sativus, owing to its strong antioxidant and anti-apoptotic potential, could be a
Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
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BACKGROUND
Crocin and safranal are the active substances of saffron and have many biological properties. In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats.
METHODS
Local inflammation was induced by intraplantar (ipl)
Role of novel terpenes in transcutaneous permeation of valsartan: effectiveness and mechanism of action.
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BACKGROUND
The greatest obstacle for transdermal delivery is the barrier property of the stratum corneum. Many approaches have been employed to breach the skin barrier; the most widely used one is that of chemical penetration enhancers. Of the penetration enhancers, terpenes are arguably the most
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