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High-dose silibinin rescue treatment for HCV-infected patients showing suboptimal virologic response to standard combination therapy.
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Incomplete suppression of hepatitis C virus (HCV) replication with persistence of minimal viremia (partial virologic response) leading to treatment failure can be observed in a significant proportion of HCV type 1-infected patients during antiviral therapy. Recently, high-dose intravenous silibinin
An open-label, randomized and multi-center clinical trial to evaluate the efficacy of Silibinin in preventing drug-induced liver injury.
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To assess the clinical efficacy and safety of Silibinin in preventing drug-induced liver injury (DILI) in the general population (high-risk patients with non-drug induced liver injury).
METHODS
A prospective, multi-center, randomized, open-label and controlled trial was conducted with 568 patients
[Amanita poisoning during pregnancy].
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A pregnant woman at the 28th gestational week and three other members of the family had mushrooms for dinner. One of these mushrooms was an Amanita mushroom. The morning after, three of them suffered from nausea, vomiting and diarrhoea. The pregnant woman was admitted to hospital, and therapy with
Mushroom poisoning--from diarrhea to liver transplantation.
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Mushroom poisoning from the genus Amanita is a medical emergency, with Amanita phalloides being the most common species. The typical symptoms of nausea, vomiting, abdominal pain, and diarrhea are nonspecific and can be mistaken for gastroenteritis. If not adequately treated, hepatic and renal
Challenges in the early diagnosis of patients with acute liver failure induced by amatoxin poisoning: Two case reports.
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BACKGROUND
Acute liver failure (ALF) induced by amatoxin-containing mushrooms accounts for more than 90% of deaths in patients suffering from mushroom poisoning. However, due to the fact that most hospitals cannot identify the species of mushrooms involved, or detect amatoxins, the early diagnosis
Four patients with Amanita Phalloides poisoning.
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Mushroom poisoning by Amanita phalloides is a rare but potentially fatal disease. The initial symptoms of nausea, vomiting, abdominal pain and diarrhea, which are typical for the intoxication, can be interpreted as a common gastro-enteritis. The intoxication can progress to acute liver and renal
Investigation and analysis of Galerina sulciceps poisoning in a canteen.
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BACKGROUND
Guizhou Province in China has an abundant resource of wild mushrooms, including numerous poisonous species which contain various toxins. The mortality rate from wild mushroom poisoning has been high in this area in recent years. Galerina sulciceps is a dangerously toxic mushroom which can
[Mushroom poisoning with a long period of development].
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A group of 87 patients with the signs of poisoning with mushrooms with along period of incubation (t = 12.4 +/- 6.2 h) has been reported. Nausea, vomiting and diarrhea dominate in the clinical picture in the first phase and hepatic and/or renal insufficiency in the second phase. Forty-one patients
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