Able to improve the spasms of SO; literature showed that it treated biliary disorders effectively.

Contains the active pharmaceutical ingredient (API) and has the effects of fighting infection, alleviating pain, promoting bile secretion and lifting muscle spasms; literature showed that Danshu Capsules effectively improved the symptoms of biliary disorders, such as pain, nausea and abdominal distension.

Sphincter of Oddi Dysfunction

Danshu Capsules (0.9g potid/day) for three months by oral

Danshu Capsules

Pinaverium Bromide (100mg potid/day) for three months by oral

Pinaverium Bromide

Zhang Yong

Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction

Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study

abdominal pain scores (baseline vs. 3 months after treatment)
Abdominal pain score based on main symptom: Degree of pain in point（0 - no pain [0 point]；1~3 - mild pain [1 point]；4~6 moderate pain [2 point]]；7~10 - severe pain [3 point]）、Frequency in times/week (No episodes[0 point]；1 time/week[1 point]；2 times/week[2 point]; 3 times/week[3 point])、Duration in days/week(No episodes[0 point]；< 1 day/week[1 point]；1-2days/week[2 points]；≥ 3days/week[3 points])
The sum of the scores for the above three items is the total score for abdominal pain.
Efficacy evaluation: reduction in abdominal pain score, as compared with the baseline
= 100%: complete remission (CR)；60%~99%: significant remission (SR)；30% ~ 59%: partial remission (PR)；0% ~ 29%: no response (NR)
Treatment response = CR + SR
Treatment response rate = (CR + SR) / the total number of patients

Changes in the CBD diameter measured by ultrasound B
Each patient is required to abstain from eating for 12 hours and then takes a measurement of the CBD diameter by ultrasound B the next morning
The measurement takes places once a month, four times totally (baseline / 4w after treatment / 8w after treatment / 12w after treatment)

Changes in hepatic enzyme levels (ALT, AST and ALP)
The measurement takes place once a month, four times totally (baseline / 4w after treatment / 8w after treatment / 12w after treatment)

The number of patients presenting the symptoms of diarrhea will be calculated at the time of enrollment (baseline) and 3 months after treatment respectively.

Incidence of adverse events (throughout the treatment)
The type and number of adverse events will be calculated at the baseline and each visit
Inquire about symptoms: rashes, pruritus, acid regurgitation, abdominal distention, diarrhea, etc.
Perform the following examinations at the last visit: blood / urine / stool test, liver / kidney function test, ECG

Zhaohui Tang

the chief surgeon of the department of General Surgery

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Post ERCP Pancreatitis

Diclofenac 90mg, 2ml/A, IM(intramuscular) injection immediately after procedure of ERCP

Diclofenac

normal saline 2ml/A, IM(intramuscular) injection immediately after procedure of ERCP

normal saline

Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine

Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis

Acute pancreatitis was defined as serum amylase at least three times the upper limit of normal range 24hours after the procedure associated with new or increased upper abdomen or epigastric pain, back pain, and epigastric tenderness and hospitalization or prolongation of existing hospitalization for at least 2 nights.

sphincter of oddi dysfunction/náusea

Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction

Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis

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