6 resultados
The tolerance changes to strophanthin in cats were studied during 7 days after occlusion of the coronary artery along with the determination of the electrolyte concentration in different areas of the myocardium. It is shown that the acute disorder of the coronary circulation produces during 2 days
Effects of histamine and serotonin on strophanthine cardiotoxicity were examined in experiments on 312 cats. It was shown that inflammation mediators exert sympathomimetic action on the myocardium and potentiate strophanthine cardiotoxicity. These effects can be prevented by premedication with the
The tolerance to strophanthin was studied in acute and subacute experiments on 76 cats at varying time after occlusion of the coronary artery branch. The beta-adrenoblocker alpheprol completely smoothed away the hypersensitivity to strophanthin after the coronary blood flow cessation while the
It has been shown in rat experiments that non-coronarogenic injury to the myocardium induced by isadrin reduces the tolerance to the cardiotoxic action of strophanthine more powerfully than coronary artery occlusion. The physical overloading until complete exhaustion induced by swimming raises the
In experiments on rabbits various effects of steroidal agents (hydrocortisone, deoxycorticosterone, beta-lipoproteids, cholesterol, saponins, digitoxin, strophanthin) on the development of sensitization and allergization at their administration during sensitization and before the resolving dose of
By using the method of the measurement of the degree of actomyosin superprecipitation of the rabbit cardiomyocytes it was shown that isolanide (0.1 mg/kg), adoniside (0.1 ml/kg), strophanthin K (0.05 mg/kg) and corglycon (0.15 mg/kg) prevented the allergic process-induced disturbance of ATP energy