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14 resultados
Anti-apoptotic effect of taxodione on serum/glucose deprivation-induced PC12 cells death.
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Taxodione, a diterpenoid from the roots of Salvia chorassanica Bunge, possesses cytotoxic, apoptotic, and antimicrobial activity. This study was designed to investigate the protective effects of taxodione on serum/glucose deprivation-induced ischemic injury in PC12 cells and related mechanisms. In
Taxodione and Extracts from Salvia austriaca Roots as Human Cholinesterase Inhibitors.
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Taxodione, an abietane diterpenoid, was isolated from Salvia austriaca transformed roots grown in in vitro conditions. The compound is known to have antibacterial, cytotoxic and anti-tumour properties. This study evaluates the ability of pure taxodione and extracts obtained from the S. austriaca
An unusual taxodione derivative from hairy roots of Salvia austriaca.
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From a root culture of Salvia austriaca, transformed with Agrobacterium rhizogenes, a new diterpenoid was isolated and its chemical structure was determined as 7-(2-oxohexyl)-11-hydroxy-6, 12-dioxo-7,9(11),13- abietatriene [= 7-(2-oxohexyl)-taxodione] on the basis of spectroscopic methods,
Antimicrobial and anti-biofilm properties of new taxodione derivative from hairy roots of Salvia austriaca.
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The aim of the present report was to evaluate antimicrobial/anti-biofilm activity of 7-(2-oxohexyl)-taxodione, a novel taxodione derivative isolated from n-hexane extract of Salvia austriaca hairy roots. Antimicrobial assays showed that 7-(2-oxohexyl)-taxodione was at least 4 times more active than
Antimicrobial and Antileishmanial Activities of Diterpenoids Isolated from the Roots of Salvia deserta.
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Four diterpenes with biological activity were isolated from Salvia deserta roots. Taxodione was considered leishmanicidal with an IC50 value of 1.46 µM (0.46 mg/L) against Leishmania donovani and also exhibited antifungal and antimicrobial activities. Ferruginol displayed the greatest activity [24-h
A new highly hydroxylated triterpene from Salvia atropatana Bunge.
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One new triterpenoid olean-18-ene-1β, 2α, 3β-triol (1) along with four known compounds were isolated from the chloroform extract of the aerial part of Salvia atropatana Bunge. The known compounds were two flavonoids, 5-hydroxy-7,4'-dimethoxyflavone (2) and 5-hydroxy-6,7,4'-trimethoxyflavone (3), an
A new triterpene from Salvia xanthocheila Boiss.
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From the chloroform extract of the aerial parts of Salvia xanthocheila, one new triterpene, together with two known diterpenes, two known flavonoids and a phytosterol was isolated. On the basis of comprehensive spectroscopic analyses, including electron ionisation mass spectra, ¹H-NMR, ¹³C-NMR, 1-D
Constituents of the roots of Salvia prionitis.
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From the roots of Salvia prionitis, a novel alkaloid named prioline (1) and a new diterpene, prineoparaquinone (2), were isolated together with taxodione; microstegiol; 8,11,13-dehydroabietane; and 2-isopropyl-8-methyl-3,4-phenanthraquinone. The structures of the new compounds were established by
Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity.
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A new ursane-type triterpenoid, 3 beta,11 alpha,21 alpha-trihydroxyurs-12-ene, named salvistamineol (1), has been isolated from the methanol extract of Salvia staminea. In addition to 1, the methanol extract yielded four known compounds and the acetone extract yielded twelve known compounds
Antioxidant diterpenoids from the roots of Salvia barrelieri.
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BACKGROUND
The phytochemical and biological studies carried out on Salvia species showed that their extracts and constituents have various biological activities.
OBJECTIVE
The aim of this study was the isolation of diterpenoids from the roots of Salvia barrelieri Ettling and the determination of the
Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation.
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Bioassay-guided fractionation of Salvia chorassanica Bunge roots for the first time led to the isolation of taxodione, ferruginol and 6-hydroxysalvinolone. Cytotoxic studies revealed that all compounds exhibited high cytotoxic activity against apoptosis-proficient HL-60 and apoptosis-resistant K562
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
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The new diterpenes brussonol (1) and iguestol (6alpha,11-dihydroxy-12-methoxy-abieta-8,11,13-triene) (2) with an icetexane and a dehydroabietane skeleton, respectively, have been isolated from hairy root cultures of Salvia broussonetii. Other previously known diterpenes, 7-oxodehydroabietane,
Genetic transformation of Salvia austriaca by Agrobacterium rhizogenes and diterpenoid isolation.
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Hairy roots of Salvia austriaca Jacq. transformed with Agrobacterium rhizogenes strain A4 were obtained and transgenic status of the roots was confirmed by polymerase chain reaction (PCR) using rolB and rolC specific primers. The root cultures growing in half-strength Gamborg (1/2 B5) liquid medium
The production and antiprotozoal activity of abietane diterpenes in Salvia austriaca hairy roots grown in shake flasks and bioreactor.
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The biomass and concentration of bioactive quinone methide-type diterpenes in hairy roots of Salvia austriaca were determined and compared with levels of these metabolites in roots of field-grown plants. The cultures were maintained in shake flasks and a nutrient sprinkle bioreactor. Diterpene
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