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6 resultados
Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis.
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A series of 21 tobacco smoke components and related compounds werere applied to mouse skin (50 female ICR/Ha Swiss mice/group) three times weekly with a low dose (5 mug/application) of benzo[a]pyrene (B[a]P). The test compounds were of five classes: aliphatic hydrocarbons, aromatic hydrocarbons,
Cytotoxic butanolides from the stem bark of Formosan Lindera communis.
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Two new butanolides, lincomolide A (1), lincomolide B (2), along with seven known compounds, isolinderanolide E, sepesteonol, beta-sitosterol, beta-sitosterol-beta-glucoside, tetradecane, nonanoic acid and decanol, were isolated from the chloroform-soluble portion of the stem bark of Lindera
New synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents.
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RhoB is expressed during tumor cell proliferation, survival, invasion, and metastasis. In malignant progression, the expression levels of RhoB are commonly attenuated. RhoB is known to be linked to the regulation of the PI3K/Akt survival pathways. Based on aliphatic amido-quaternary ammonium salts
Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4.
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OBJECTIVE
To investigate the cytotoxic activity of endophytic fungi isolated from mangrove fungi.
METHODS
In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated sequencers. Blast search
Bielschowskysin, a gorgonian-derived biologically active diterpene with an unprecedented carbon skeleton.
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Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic
The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceace).
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The plant, Typhonium flagelliforme (Araceae), commonly known as the "rodent tuber" in Malaysia, is often used as an essential ingredient of herbal remedies for alternative cancer therapies. The hexane extract of this plant was evaluated for cytotoxic activity against in vitro culture on P388 murine
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