The present invention relates to a compound as represented by formula (I), which is a condensation product of a theanine derivative and a carboxylic acid coumarin derivative, compounds as represented by formula (II) and formula (III), both of which are intermediates of the condensation product, a method for preparing these compounds, a pharmaceutical composition comprising the compounds, and a use thereof in preparing a medicament for prevention and treatment of tumors, inflammation, cardiovascular diseases, immune deficiency diseases and the like. ##STR00001## Wherein, TABLE-US-00001 (Ia) R.dbd.CH.sub.3 R.sub.1.dbd.H R.sub.2.dbd.H (Ib) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.H R.sub.2.dbd.H (Ic) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.Cl R.sub.2.dbd.H (Id) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.Br R.sub.2.dbd.H (Ie) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.F R.sub.2.dbd.H (If) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.NO.sub.2 R.sub.2.dbd.H (Ig) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.Cl R.sub.2.dbd.Cl (Ih) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.Br R.sub.2.dbd.Br (Ii) R.dbd.CH.sub.2CH.sub.3 R.sub.1.dbd.NH.sub.2 R.sub.2.dbd.H ##STR00002## Wherein, TABLE-US-00002 (IIa) R.dbd.CH.sub.3 (IIb) R.dbd.CH.sub.2CH.sub.3 ##STR00003## Wherein, TABLE-US-00003 (IIIc) R.sub.1.dbd.Cl R.sub.2.dbd.H (IIId) R.sub.1.dbd.Br R.sub.2.dbd.H (IIIe) R.sub.1.dbd.F R.sub.2.dbd.H (IIIf) R.sub.1.dbd.NO.sub.2 R.sub.2.dbd.H (IIIg) R.sub.1.dbd.Cl R.sub.2.dbd.Cl (IIIh) R.sub.1.dbd.Br R.sub.2.dbd.Br

SHANDONG YINGDONG YINGHAO BIOTECHNOLOGY, INC.

Shandong Yingdong Yinghao Biotechnology, Inc.

Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof

An intervention for sleep disorders comprises: collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines improves tryptophan availability and sleep quality, and allows individuals to sleep better with fewer side effects. The composition promotes high-quality, deep sleep.

Losso; Jack N.

Estrada Andino; Jose Daniel

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

Composition and method for improving sleep duration and quality

An intervention for sleep disorders comprises collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines improves tryptophan availability and sleep quality, and allows individuals to sleep better with fewer side effects. The novel composition promotes high-quality, deep sleep.

Disclosed herein are compositions comprising tea derived components which are useful in decreasing elevated blood pressures, lowering LDL and/or lowering inflammatory markers of cardiovascular disease. Specifically exemplified herein are compositions comprising predetermined amounts of L-theanine and EGCG, and methods of using same to improve cardiovascular health.

theanine/inflamación

Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof

Composition and method for improving sleep duration and quality

Composition and method for improving sleep duration and quality

Tea-derived compositions and methods of using same for cardiovascular health

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