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12 resultados
Comparative study of the acute lung toxicity of pure cobalt powder and cobalt-tungsten carbide mixture in rat.
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Alveolitis progressing to lung fibrosis has been reported in workers exposed to cobalt containing dust (e.g., tungsten carbide-cobalt mixture as produced by the hard metal industry) but rarely following exposure to pure cobalt dust (e.g., in cobalt-producing factories). We have previously
Xanthine oxidase-derived oxygen radicals induce pulmonary edema via direct endothelial cell injury.
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Pulmonary hypoperfusion/ischemia-reperfusion (I/R) may initiate ARDS (nonhydrostatic pulmonary edema). Endothelial damage via xanthine oxidase (XO)-derived oxygen radicals (O2*) may mediate I/R injury. We previously documented Factor VIII antigen (F8) as a marker for endothelial injury. The purpose
Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.
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The contribution of toxic O2 metabolites to cerebral ischemia reperfusion injury has not been determined. We found that gerbils subjected to temporary unilateral carotid artery occlusion (ischemia) consistently developed neurologic deficits during ischemia with severities that correlated with
A comparison of two techniques for tungsten carbide ring removal.
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BACKGROUND
Emergency physicians may have difficulty removing modern rings made of hard metals such as titanium and tungsten carbide. These metals are exceptionally difficult or impossible to remove using standard ring cutters. Numerous alternative techniques for removal have been described,
Effects of cemented tungsten carbide dust on rat lungs following intratracheal injection of saline suspension.
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In order to examine the effect of cemented tungsten carbide dust on the animal lung, saline suspensions were intratracheally administered into the lungs of rats in a single dosage. About one-fifth of the animals died during the first three days. The acute response of the lungs was hemorrhagic edema
Characteristics of sustained blood-brain barrier opening and tissue injury in a model for focal trauma in the rat.
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Minor stab wounding of rodent brain by needle or razor blade is a standard model for immunohistochemical investigations of secondary neuronal degeneration and scarring. Opening of the blood-brain barrier (BBB) to plasma molecules and inflammatory cells is integral to the secondary injury process. To
[Pathology of cardiac lesions induced by radiofrequency ablation in an experimental model].
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Radiofrequency catheter ablation is increasingly being used for the treatment of several tachyarrhythmias. The main aim of this paper is to describe the lesional pathology produced by this type of current. Fourteen Wistar rats (mean weight 300 g) were subjected to discharges of a 700 KHz, pure,
Time course of acute neuroprotective effects of lidocaine evaluated by brain impedanciometry in the global ischemia model.
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Voltage-activated sodium channels play a primary role during ischemic brain edema and thus are a pharmacological target for therapy. Lidocaine, a sodium channel blocker, was tested in male Sprague-Dawley rats anesthetized with thiobarbital (60 mg·kg(-1) i.p.) and perfused i.v. with Ringer's solution
Stereotactic single high dose radiation therapy of benign intracranial meningiomas.
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Seventeen patients with intracranial meningiomas were treated with single high dose irradiation at the German Cancer Research Center in Heidelberg. Indications for radiosurgery included unresected tumors, gross disease remaining despite surgery, and recurrences. Therapy was carried out by a
Monochromatic (red-free) photography and ophthalmoscopy of the peripapillary retinal nerve fiber layer.
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The appearance of the peripapillary retinal nerve fiber layer (PRNFL) is crucial in the evaluation of patients with presumed optic neuropathies as well as in the differentiation of true optic disc edema from pseudopapilledema. Monochromatic (red-free) photography performed at 2 + magnification with
Morphologic changes in the guinea pig cochlea following cochleostomy--a preliminary scanning electron microscope study.
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Fistulization of the membranous labyrinth via a surgically created endolymphatic-perilymphatic shunt (cochleosacculotomy) is currently being advocated as a treatment for endolymphatic hydrops. As a preliminary study to the investigation of the effects of labyrinthine fistulization on the hydropic
Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury.
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LPS and selected cytokines upregulate xanthine dehydrogenase/xanthine oxidase (XDH/XO) in cellular systems. However, the effect of these factors on in vivo XDH/XO expression, and their contribution to lung injury, are poorly understood. Rats were exposed to normoxia or hypoxia for 24 h after
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