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Influence of physical activity intensity and aerobic fitness on the anthropometric index and serum uric acid concentration in people with obesity.
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OBJECTIVE
Physical activity (PA) is considered an important approach to prevent and treat obesity and hyperuricemia. The purpose of the present study was to examine the influence of PA intensity and aerobic fitness on anthropometric indices and serum uric acid in obese individuals.
METHODS
PA was
The Effect of the Mediterranean Diet on Serum Total Antioxidant Capacity in Obese Patients: A Randomized Controlled Trial.
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OBJECTIVE
The aim of this work was to evaluate the combined effect of physical activity and 1 and 12 months' adherence to Mediterranean diet (MD) on serum total antioxidant capacity (TAC) in obese patients, as well as factors contributing to TAC.
METHODS
One hundred twenty-four patients were
Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene.
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All humans are double knockouts. Humans lack the ability to synthesize vitamin C due to a mutation in L-gulono-lactone oxidase that occurred during the late Eocene, and humans have higher serum uric acid levels due to a mutation in uricase that occurred in the mid Miocene. In this paper we review
Gender-specific association of serum uric acid with metabolic syndrome and its components in juvenile obesity.
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BACKGROUND
Hyperuricemia has been implicated in the pathogenesis of obesity and related metabolic abnormalities. Studies on the association between serum uric acid (sUA) and metabolic syndrome (MetS) in juvenile obesity are scant. The effect of gender has not been evaluated.
METHODS
sUA (uricase
Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations.
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All human beings are uricase knockouts; we lost the uricase gene as a result of a mutation that occurred in the mid-Miocene epoch approximately 15 million years ago. The consequence of being a uricase knockout is that we have higher serum uric acid levels that are less regulatable and can be readily
Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes.
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Fructose-containing added sugars, such as sucrose and high-fructose corn syrup, have been experimentally, epidemiologically, and clinically shown to be involved in the current epidemics of obesity and diabetes. Here we track this history of intake of sugar as it relates to these epidemics. Key
The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease.
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Humans have relatively low plasma ascorbate levels and high serum uric acid levels compared to most mammals due to the presence of genetic mutations in l-gulonolactone oxidase and uricase, respectively. We review the major hypotheses for why these mutations may have occurred. In particular, we
Serum uric acid is a determinant of metabolic syndrome in a population-based study.
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BACKGROUND
Determination of serum uric acid concentrations and role in risk of metabolic syndrome (MS) were investigated in 1877 participants in a cross-sectional population-based study including a brief follow-up.
METHODS
The MS was identified by modified criteria of the Adult Treatment Panel III,
No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.
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Urate is the metabolic end point of purines in humans. Although supra-physiological plasma urate levels are associated with obesity, insulin resistance, dyslipidemia, and hypertension, a causative role is debated. We previously established a mouse model of hyperuricemia by liver-specific deletion of
The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus.
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BACKGROUND
Hyperuricemia is associated with obesity. The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy
New and improved strategies for the treatment of gout.
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The Western world appears to be in the midst of the third great gout epidemic of all time. In this century, gout is increasing in prevalence despite an increased understanding of its risk factors and pathophysiology, and the availability of reasonably effective treatment. The main cultural factors
Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology.
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OBJECTIVE
The metabolic syndrome refers to a constellation of signs including abdominal obesity, elevated serum triglycerides, low HDL-cholesterol, elevated blood pressure, and insulin resistance. Today approximately one third of the adult population has the metabolic syndrome. While there is little
Recent advances in the management of gout and hyperuricemia.
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OBJECTIVE
To review the recent advances in the management of gout and hyperuricemia.
RESULTS
The first quality indicators for gout management have been proposed. Selective COX II inhibitors, as well as traditional NSAIDs, are effective in acute gout. A new xanthine oxidase inhibitor, febuxostat, and
[The phylogenetic theory of general pathology. The development of seven biological functions, seven specific ones and etiological factors of metabolic epidemics, millions years' common pathogenesis and basics of prevention.]
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The clearer realization is coming that in general biology, medicine, historical science, in biologic phylogenetic anamnesis of Homo sapiens a task exists only one by its significance and unresolved still: to establish historical succession of becoming of specific etiologic factors of every metabolic
Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men.
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BACKGROUND
Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men.
METHODS
The study included 3,978 urban Chinese
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