Moderate of severe neonatal encephalopathy

Neonatal Encephalopathy

Sudhin Thayyil

Magnetic Resonance Biomarkers in Neonatal Encephalopathy

A Multicentre Prospective Study on Magnetic Resonance Biomarkers in Neonatal Encephalopathy

Consultant Neonatologist

Thayyil, Sudhin

Standard acute coronary syndrome treatment as per hospital protocol
Pre-hospital supplemental oxygen administered via Hudson mask at a flow rate of 8L/min
In-hospital oxygen as per hospital protocol

Standard acute coronary syndrome treatment as per hospital protocol
No oxygen pre-hospital or in-hospital unless the oxygen saturation falls below 94% in which case oxygen will be administered via nasal cannulae (4L/min) or Hudson mask (8L/min) and titrated to achieve oxygen saturation of 94%.

Acute Myocardial Infarction

Coronary Artery Disease

Pre-hospital supplemental oxygen administered via Hudson mask at a flow rate of 8L/min
In-hospital oxygen as per hospital protocol

Oxygen therapy

No oxygen pre-hospital or in-hospital unless the oxygen saturation falls below 94% in which case oxygen will be administered via nasal cannulae (4L/min) or Hudson mask (8L/min) and titrated to achieve oxygen saturation of 94%.

No oxygen therapy

Peninsula Private Hospital

Alfred Hospital

Western Hospital

Royal Melbourne Hospital

St Vincents Hospital

Austin Hospital

Ambulance Victoria

Box Hill Hospital

Monash Medical Centre

Frankston Hospital

Air Verses Oxygen In myocarDial Infarction Study

A Randomised Controlled Trial of Oxygen Therapy in Acute Myocardial Infarction (AVOID - Air Verses Oxygen In myocarDial Infarction Study)

The primary end-point for the study will be infarct size at hospital discharge which will be ascertained by the routinely collected cardiac biomarkers during hospital admission such as cardiac troponin I (cTnI) and creatine kinase (CK)Infarct size will be evaluated via blood test on admission and then 6 hourly tests for 48 hours and 12 hourly measurements between 48 hours and 72 hours. Infarct size will be measured by:
Mean and peak cTnI
Mean and peak CK
The area under the curve of CK and cTnI release over the first 72 hours of reperfusion.

TIMI - Thrombolysis in Myocardial infarction score

Death, recurrent myocardial infarction, and re-hospitalization measured at 6 months

Magnetic resonance imaging (MRI) measurement of infarct size as percent of area at risk determined with T2-weighted MRI (in small sub set of patients) at day 4 and repeated at 6 months.

victoria/hypoxia

Magnetic Resonance Biomarkers in Neonatal Encephalopathy

Air Verses Oxygen In myocarDial Infarction Study

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