Standard acute coronary syndrome treatment as per hospital protocol
Pre-hospital supplemental oxygen administered via Hudson mask at a flow rate of 8L/min
In-hospital oxygen as per hospital protocol

Standard acute coronary syndrome treatment as per hospital protocol
No oxygen pre-hospital or in-hospital unless the oxygen saturation falls below 94% in which case oxygen will be administered via nasal cannulae (4L/min) or Hudson mask (8L/min) and titrated to achieve oxygen saturation of 94%.

Acute Myocardial Infarction

Coronary Artery Disease

Pre-hospital supplemental oxygen administered via Hudson mask at a flow rate of 8L/min
In-hospital oxygen as per hospital protocol

Oxygen therapy

No oxygen pre-hospital or in-hospital unless the oxygen saturation falls below 94% in which case oxygen will be administered via nasal cannulae (4L/min) or Hudson mask (8L/min) and titrated to achieve oxygen saturation of 94%.

No oxygen therapy

Peninsula Private Hospital

Alfred Hospital

Western Hospital

Royal Melbourne Hospital

St Vincents Hospital

Austin Hospital

Ambulance Victoria

Box Hill Hospital

Monash Medical Centre

Frankston Hospital

Air Verses Oxygen In myocarDial Infarction Study

A Randomised Controlled Trial of Oxygen Therapy in Acute Myocardial Infarction (AVOID - Air Verses Oxygen In myocarDial Infarction Study)

The primary end-point for the study will be infarct size at hospital discharge which will be ascertained by the routinely collected cardiac biomarkers during hospital admission such as cardiac troponin I (cTnI) and creatine kinase (CK)Infarct size will be evaluated via blood test on admission and then 6 hourly tests for 48 hours and 12 hourly measurements between 48 hours and 72 hours. Infarct size will be measured by:
Mean and peak cTnI
Mean and peak CK
The area under the curve of CK and cTnI release over the first 72 hours of reperfusion.

TIMI - Thrombolysis in Myocardial infarction score

Death, recurrent myocardial infarction, and re-hospitalization measured at 6 months

Magnetic resonance imaging (MRI) measurement of infarct size as percent of area at risk determined with T2-weighted MRI (in small sub set of patients) at day 4 and repeated at 6 months.

Ms. Rowan Frew

A.Professor Stephen Bernard

Bayside Health

Monash University

Baker IDI Heart and Diabetes Institute

FALCK Foundation

Usual post-TIA/minor stroke care as per current healthcare system protocol will be given to patients in control group and details will be recorded.

Receiving usual post-TIA/minor stroke care plus 'The Healthy Brain Rehabilitation Manual'.

Receiving usual post-TIA/minor stroke care plus 'The Healthy Brain Rehabilitation Manual' and a pedometer with telephone follow-up from a General Practitioner.

Receiving usual post-TIA/minor stroke care plus 'The Healthy Brain Rehabilitation Manual' and a pedometer with telephone follow-up from a Stroke nurse.

Cerebrovascular Disorders

The Healthy Brain Rehabilitation Manual is a home-based rehabilitation manual developed for the post-TIA and minor stroke population caused by ischaemic events. The manual addresses all the secondary prevention factors required post-ischaemic TIA/minor stroke, e.g. smoking cessation, physical activity promotion.

'The Healthy Brain Rehabilitation Manual'

Pedometer used to measure step counts as an objective measurement of level of physical activity.

Pedometer

Usual care provided by healthcare system for patients who suffer a TIA or minor stroke will be recorded and form 'active comparator' control.

Usual care

Telephone follow-up by either a General Practitioner (GP) or Stroke nurse.

Telephone follow-up

Ulster Hospital

Antrim Area

Craigavon Area Hospital

SPRITE - A Feasibility and Pilot Study

Stroke Prevention Rehabilitation Intervention Trial of Exercise - SPRITE - A Feasibility and Pilot Study

Recruitment rate calculated as percentage of potentially eligible patients who agree to participate

Physical activity measured as step count (steps/day) assessed at baseline and 12 weeks, to determine extent of change. Also accelerometer data over the same timeframe.

BMI measured at baseline and 12 weeks, to determine extent of change

Quality of life assessed at baseline and 12 weeks, to determine extent of change

Systolic and diastolic blood pressure measured at baseline and 12 weeks.

Distance walked in two minutes assessed by the two minute walk test at baseline and 2 weeks to determine extent of change in measurement

Numbers of patients who complete review assessments at 12 weeks, expressed as percentage of those who agree to participate and attend baseline assessment.

Prof Frank Kee

Professor of Public Health

Queen's University, Belfast

National Institute for Health Research, United Kingdom

The intervention groups will be getting access to a home-based rehabilitation, 'The Healthy Brain Rehabilitation Manual', telephone follow-up with either a GP or stroke nurse and a pedometer.

victoria/infartarse

Air Verses Oxygen In myocarDial Infarction Study

SPRITE - A Feasibility and Pilot Study

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