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Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology

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Schistosomiasis mansoni is a water-borne disease caused by helminth Schistosoma mansoni (S. mansoni), in which adult worms deposit eggs in mesenteric blood vessels. Schistomiasis prevalence in the fishing communities in East Africa, and particularly in the Lake Victoria region, exceeds 60% and there

Modulation of Hyperinflammation in COVID-19

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The coronavirus disease 2019 (COVID-19) is a novel virus that was first reported in December 2019 from Wuhan, China. So far, over 8,000,000 cases have been reported around the globe with >400,000 reported deaths overwhelming hospitals and constraining resources. Death is mainly due to severe acute

B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis

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Primary Biliary Cirrhosis (PBC) is a liver disease that predominantly affects females, can present for the first time at any age, and which develops over many years. It is caused by the immune system attacking the body's own tissues. People with PBC frequently experience profound fatigue or

The Gut Microbiota in Obsessive-Compulsive Disorder

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Phase I of the study will involve 25 healthy controls (no anxiety or mood disorders) and 25 outpatients with primary DSM 5 OCD. Participants ages 18-65 will be assessed using the Mini International Neuropsychiatric Interview (MINI) to determine whether criteria for a primary OCD diagnosis is met

The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

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The investigators plan to conduct a feasibility pilot prospective, multi-centre, randomised, open-label, trial in ICU patients with septic shock to test whether the intravenous administration of high dose Vitamin C (6g/d), Thiamine (400mg/d) and Hydrocortisone (200mg/d) for a maximum of ten days

Subacromial Injections for Shoulder Subacromial Pain Syndrome - Anterolateral vs Posterior Approach

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Patients who present with subacromial pain syndrome (disorders such as subacromial bursitis, rotator cuff tendinopathy, calcific tendinitis, subacromial inflammation with a partial thickness rotator cuff tear) to the orthopaedic outpatient clinic are treated initially with a subacromial steroid

Effect of Supplementation With Glutamine and Exercise in Women With HIV/AIDS

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The aim of the present study was to investigate the effect of a short period of supplementation with glutamine dipeptide (GDP) in the acute responses to resistance training on people living with HIV/AIDS i the following healthy indicators: executive functions, stress oxidative markers,

Cerebrovascular Outcomes in Ischemic Heart Disease

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This is a randomized control trial, with randomization nested within rationally-formed groups. Three major groups will be assessed: 1) Coronary artery disease (CAD) patients, 2) Metabolic Syndrome (MetS), and 3) healthy Control (CTL) participants. Allocation into the Healthy CTL versus MeTS groups

Endomicroscopy and Graft-versus-host Disease

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Graft-versus-host disease (GvHD) represents a major cause for morbidity and mortality in patients who underwent haematopoietic stem cell transplantation (HSCT) [1]. In the gastrointestinal tract as one of the main target organs of GvHD diagnosis may be difficult because of many similar presenting

Prevalence of Sleep Apnoea in Adolescents

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Study Design It is a cross-sectional, population-based study. Subjects who are found to meet all the inclusion and none of the exclusion criteria will be recruited. Participants will complete a set of sleep-related questionnaires, undergo anthropometric measurements, home polysomnographic (PSG)

ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial

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The role of aspirin as a novel therapy for ARDS. Aspirin inhibits cyclo-oxygenase enzymes, therefore preventing the formation of lipid mediators including thromboxane A2 (TxA2) and pro-inflammatory prostaglandins from arachidonic acid. TxA2 is required for platelet degranulation and aggregation.

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