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Página 1 desde 24 resultados
Convalescent Plasma for Treatment of COVID-19: An Exploratory Dose Identifying Study
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Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Through BCG Vaccine
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Since the beginning of 2020, SARS-CoV-2 spread rapidly throughout China and the rest of the world, with on 27 February 2020 the first detected case in the Netherlands.
According to the WHO, Health-care workers (HCW) face an elevated risk of exposure to - and infection of Covid-19.
Bacillus
Dose-ranging Study of an Investigational Yellow Fever Candidate Vaccine in Adults
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Study duration per participant is approximately 6 months.
Safety and Tolerability of an Antibody Against Yellow Fever Virus (TY014) in Humans
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Safety Arm (1A):
Safety Arm is a phase 1A First-in-Human, Time Lagged, Single Ascending Dose Study of TY014 in Healthy Adult Volunteers.
Safety, tolerability and PK of TY014 will be assessed. The dose escalation will include 27 healthy volunteers in five (5) dose cohorts:
- 0.5 mg/kg, N = 2 TY014 +
Pilot Study to Detect DENGUE Virus in Sperm
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Dengue fever is a major cause of illness and death worldwide. The disease is caused by dengue virus (DENGV) which gets transmitted to humans by the bites of infected Aedes mosquitoes. The dengue virus is a flavivirus genus as for example the West Nile virus, yellow fever virus or Zika virus. In
Yellow Fever Vaccine in Patients With Rheumatic Diseases
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Validation of a Proteomic Signature and Assessment of Viremia in Children With Fever Without Source
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Immunogenicity and Safety of the Yellow Fever Vaccine in HIV Infected Individuals
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Study of a Live Attenuated Chikungunya Vaccine in a Previously Epidemic Area
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The clinical study to be conducted under this IND will assess the safety of MV-CHIK in a previously epidemic area (Puerto Rico).
A total of 100 healthy volunteers, 50 of whom are seropositive to Chikungunya at baseline and 50 of whom are seronegative, will be randomized in a 4:1 ratio to receive
RT-PCR on Urine Samples: Added Value for the Diagnosis of Chikungunya Virus Infection
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Objectives
1. To assess the added value of RT-PCR for CHIKV on urine samples for diagnosing CHIKV infection in comparison to the reference methods.
2. To describe the kinetics of RT- PCR for CHIKV on urine samples for diagnosing CHIKV infection over time.
Study design, population, materials and
Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore
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This trial is a single centre, double-blind, double-dummy, placebo-controlled parallel-group, dose ranging study in adult participants with uncomplicated dengue fever. The study will be conducted in two parts:
In Part 1, 72 otherwise healthy participants (18 participants per group, assuming up to 2
Diagnostic of Puumala Virus Infection in France
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Hantaviruses constitute one of the 5 genera in the family Bunyaviridae and are associated with several natural host species including rodents, insectivores and bats. Infection of these species remains unapparent. Transmission of the virus between individuals occurs through direct contact or through
Yellow Fever Vaccination Under Low Dose Methotrexate Therapy
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The study will be conducted in the form of a multi-center open-label prospective observational controlled pilot study. 15 patients under low dose methotrexate treatment and 15 healthy controls with an indication for yellow fever vaccination will be included. The study duration will be 28 days for
Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins
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The population to be studied will consist of neonates born to mothers presenting with clinical symptoms of Chikungunya within six days before and two days after childbirth. These neonates will therefore be exposed to a high risk of developing a severe form of Chikungunya infection. In most cases the
ValGanciclovir Versus ValAcyclovir for Viral Prophylaxis in Kidney Transplantation
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Herpes viruses such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV) cause considerable morbidity and mortality post-kidney transplant. Even subclinical CMV and/or EBV viremia have been associated with deterioration in kidney transplant function. Currently, valganciclovir (valG) is the primary
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