PRF membrane is added to the bone block to evaluate if any effect on bone healing, soft healing, post-operativ pain

A standard bone augmentation procedure, which is weel-described is performed to compare the outcome of the test group

Tooth-loss

The PRF membrane can be considered as a biological membrane

PRF is added in the test group.

Department of Dentistry and Oral Health

The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control)

Platelet Rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation. A Randomized Controlled Study Comparing an Autogenous Bone Graft Covered by a Platelet Rich Fibrin (PRF) Membrane (Test Group) or an Anorganic Bovine Bone Substitute and a Resorbable Collagen Barrier Membrane (Control Group)

The change of the augmented bone volume is assessed by comparing CBCT scans at different timepoint: Baseline=Before bone augmentation;After bone augmentation=Immediate after bone augmentation; Follow-up= Prior to implant installation (6 month after the primary bone augmentation). The volumetric bone changes over time were calculated as bone resorption rate, i.e. the difference in bone volume two weeks after bone augmentation and bone volume 6 months after augmentation.

A cylindrical biopsy of the augmented region is retrieved perpendicularly to the lateral aspect of the augmented bone 6 month after the primary bone augmentation (in the same surgical phase as the implant installation). The bone biopsies are evaluated by histological and histomorphometric analyses with focus on vital bone, non-vital bone, soft tissue, and blood vessels

Implant survival is registered at the final follow-up. Implant failure is defined as clinically visible implant mobility or removal of a stable implant due to progressive peri-implant bone loss or infection.

University of Aarhus

Some of the data anlysis is masked. The examiner is blinded when performing the CBCT scan analysis of the volume (Study 2) and the histological assessment of the bone biopsies (Study 3)

Dental implant insertion, material polyetheretherketone

Dental implant insertion, material titanium group 5

dental implant insertion, material zirconia

dental implant insertion, material titanium group 4

Dental Implant Failure Nos

Wound Heal

Local anesthesia, flap preparation, dental implant insertion, flap suture, healing abutment insertion. Peri-implant soft tissue samples taken prior to implant placement and 24 hours after.

dental implant

Department of Oral and Maxillofacial Sciences. Section of Periodontics.Sapienza, University of Rome

Soft Peri-implant Tissue Around Different Abutment Materials

Features of Peri-implant Soft Tissue Early Healing Around Different Abutment Materials

The early healing of soft peri-implant tissues will be interpreted through the activity of myofybroblasts

Andrea Pilloni MD DDS MS

MD DDS MS

University of Roma La Sapienza

Max-Planck Institute of Molecular Cell Biology and Genetics

Patients of more than 18 years old without systemic disease/ disorders, smokers of less 5 cigarettes per day, periodontally healthy or treated with full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) ≤ 15% at baseline with edentulous space needing an all on four or all on six treatment with overdenture width of the keratinized gingiva ≥ 2 at the level of the crest

zirconium/dental caries

The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control)

Soft Peri-implant Tissue Around Different Abutment Materials

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