Exploration of Neuropathic Pain Induced by Oxaliplatin Electrophysiological Approach
Märksõnad
Abstraktne
Kirjeldus
Main objective:
it is, in cancer patients chronically treated with oxaliplatin (over 5 courses) and exhibiting signs of neuropathy, to correlate the quantitative changes in the thermal sensitivity to hot and cold (Thermotest, Quantitative Sensory Testing QST ) with any changes in the ion conductance chlorine measured by electrophysiological technique (SUDOSCAN).
Secondary objectives:
- Correlating the results obtained with both types of techniques and with the descriptive parameters of the population included.
- Understand the importance of regulating the activity of the chloride channel in the development of neuropathy induced by oxaliplatin.
Methodology :
Prospective study, single center, intervention in routine care. Time study: February 2015 - October 2016
1. Evaluation of neuropathy by electrophysiological methods (SUDOSCAN) The SUDOSCAN is a new technology fast and non-invasive to quantify the degree of neuropathy objectively through evaluation of chloride conductance at the skin of the palms and the soles of pieds4,5.
2. Evaluation of neuropathy by devices for quantitative measurement of neuropathic pain
The pain symptoms was evaluated through various semi-objective neuropathy quantification tools (Quantitative Sensory Testing devices) 6:
- The Thermotest (Somedic®): medical device that measures the thermal sensitivity thresholds to cold and hot: cold sensitivity threshold, threshold of sensitivity to hot, cold pain threshold, pain threshold warm. These stimuli are transmitted by the fiber Adelta and C. Since dysesthesia to thermal stimuli (allodynia in acute and chronical hypoesthesia) are typical of oxaliplatin, Thermotest is fundamental.
- Questionnaire NPSI (Neuropathic Pain Symptom Inventory) widely used in the field and validated.
3. Statistical Analysis: Professor Gilles Chatellier, statistician (Clinical Research Unit, Hôpital Européen Georges Pompidou) will bring its expertise in statistical analysis.
NB: For each subject will be awarded an identifier (simple counter: increment as and measurement of inclusions) and the data will be entered on a computer file which will be sent to the statistician in charge of the analysis. There will be no exchange of personal data for this study is single center on the site GHPSJ.
Development of the study:
- Inclusion of patients treated with oxaliplatin from 6th cycle (FOLFOX protocols FOLFIRINOX, EOX, GEMOX, EOF, XELOX).
- Expected duration of patient recruitment: 9 months
- Number of patients to recruit and duration of participation for each patient: Based on 75 patients seen in 9 months in GHSPJ the oncology department for cancer of the digestive tract, and knowing that the prevalence of neuropathic pain in oxaliplatin is 50-70% (Attal 2009), the investigators plan to include at least 36 patients in this period of 9 months.
Kuupäevad
| Viimati kinnitatud: | 08/31/2017 |
| Esmalt esitatud: | 06/28/2016 |
| Hinnanguline registreerumine on esitatud: | 07/07/2016 |
| Esmalt postitatud: | 07/10/2016 |
| Viimane värskendus on esitatud: | 09/03/2017 |
| Viimati värskendus postitatud: | 09/05/2017 |
| Õppe tegelik alguskuupäev: | 04/03/2016 |
| Eeldatav esmane lõpetamise kuupäev: | 04/12/2016 |
| Eeldatav uuringu lõpetamise kuupäev: | 06/29/2017 |
Seisund või haigus
Sekkumine / ravi
Device: All patients
Device: All patients
Device: All patients
Faas
Käerühmad
| Arm | Sekkumine / ravi |
|---|---|
| Experimental: All patients Measure of painful neuropathy for al patients with thermotest and sudoscan Devices and Neuropathic Pain Symptom Inventory. | Device: All patients Measure of painful neuropathy with thermotest |
Abikõlblikkuse kriteeriumid
| Õppimiseks sobivad vanused | 18 Years To 18 Years |
| Uuringuks kõlblikud sood | All |
| Võtab vastu tervislikke vabatahtlikke | Jah |
| Kriteeriumid | Inclusion Criteria: - Patient newly treated with oxaliplatin - Patient suffering from any type of cancer treated with oxaliplatin - Man or Woman over 18 Exclusion Criteria: - Patient with brain or leptomeningeal metastases - Patient previously treated with cisplatin - Patient addicted to alcohol - Diabetic patient with peripheral neurological disorders - Patient receiving calcium or magnesium salts intravenously - Patient suffering from peripheral neuropathy - Patient suffering from psychiatric disorders - Patient treated with at least one of the following drug: venlafaxine, carbamazepine, gabapentin, pregabalin, clomipramine, amitriptyline, imipramine, duloxetine. |
Tulemus
Esmased tulemusnäitajad
1. Evaluation of neuropathy by electrophysiological methods using SUDOSCAN [Day 1]
Sekundaarsed tulemusmõõdud
1. Evaluation of neuropathy by devices for quantitative measurement of neuropathic pain [Day 1]
2. NPSI ange of Characterization of pain neuropathy [Day 1]
