Vasopressin and V2 Receptor in Meniere's Disease
Märksõnad
Abstraktne
Kirjeldus
Methods: Between 1998 and 2006, we enrolled and assigned 105 intractable Meniere's patients to examine plasma vasopressin during remission of vertigo attacks (controls: 30 patients with chronic otitis media). Using the real-time PCR method, we examined V2R mRNA expression in the endolymphatic sac in 12 patients (controls: 6 patients with acoustic neurinoma). By means of cell culture and cyclic AMP assay, we also examined cyclic AMP activity in the endolymphatic sac in 3 patients (controls: 3 patients with acoustic neurinoma).
Kuupäevad
| Viimati kinnitatud: | 12/31/2007 |
| Esmalt esitatud: | 01/09/2008 |
| Hinnanguline registreerumine on esitatud: | 01/21/2008 |
| Esmalt postitatud: | 01/22/2008 |
| Viimane värskendus on esitatud: | 03/27/2016 |
| Viimati värskendus postitatud: | 03/28/2016 |
| Õppe tegelik alguskuupäev: | 03/31/1998 |
| Eeldatav esmane lõpetamise kuupäev: | 08/31/2005 |
| Eeldatav uuringu lõpetamise kuupäev: | 08/31/2005 |
Seisund või haigus
Sekkumine / ravi
Genetic: 1. Meniere's disease
Faas
Käerühmad
| Arm | Sekkumine / ravi |
|---|---|
| Experimental: 1. Meniere's disease Patients were eligible for enrollment if they had received a clinical diagnosis of Meniere's disease according to the 1995 AAO-HNS criteria (Committee, 1995). These criteria can be briefly described as follows: 1) Repeated attacks of vertigo: A definitive spell is spontaneous vertigo lasting at least 20 minutes. A mixed type of spontaneous nystagmus is observed during attacks. 2) Fluctuating cochlear symptoms: The hearing test usually reveals a marked fluctuation of the threshold in the low and middle tone range. | Genetic: 1. Meniere's disease plasma vasopressin, V2 receptor, cyclic AMP |
| No Intervention: 2. Acoustic neurinoma Diagnosed by CT and/or MRI |
Abikõlblikkuse kriteeriumid
| Õppimiseks sobivad vanused | 20 Years To 20 Years |
| Uuringuks kõlblikud sood | All |
| Võtab vastu tervislikke vabatahtlikke | Jah |
| Kriteeriumid | Inclusion Criteria: - Patients were eligible for enrollment if they had received a clinical diagnosis of Meniere's disease according to the 1995 AAO-HNS criteria (Committee, 1995). These criteria can be briefly described as follows: 1. Repeated attacks of vertigo: A definitive spell is spontaneous vertigo lasting at least 20 minutes. A mixed type of spontaneous nystagmus is observed during attacks. 2. Fluctuating cochlear symptoms: The hearing test usually reveals a marked fluctuation of the threshold in the low and middle tone range. Exclusion Criteria: - Any other neuro-otologic diseases. |
Tulemus
Esmased tulemusnäitajad
1. plasma vasopressin level and V2 receptor mRNA in the endolymphatic sac in Meniere's disease vs controls [prospective]
Sekundaarsed tulemusmõõdud
1. cyclic AMP activity in the endolymphatic sac in Meniere's disease vs controls [prospective]
