artocarpin

Gray platelet syndrome (GPS), or platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood platelets, and the release of proteins normally contained in these granules into the marrow, causing myelofibrosis.GPS is primarily inherited in an autosomal recessive manner, and the gene that is mutated in GPS has been mapped to chromosome 3p and identified as NBEAL2. NBEAL2 encodes a protein containing a BEACH ...