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Solasodine-3-O-β-d-glucopyranoside kills Candida albicans by disrupting the intracellular vacuole.

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The increasing incidence of fungal infections and emergence of drug resistance underlie the constant search for new antifungal agents and exploration of their modes of action. The present study aimed to investigate the antifungal mechanisms of solasodine-3-O-β-d-glucopyranoside (SG) isolated from

Natural product solasodine-3-O-β-D-glucopyranoside inhibits the virulence factors of Candida albicans.

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Candida albicans undergoes yeast-to-hyphal transition that has been recognized as a virulence factor as well as the key point for the development of mature biofilm. In this study, we found that a natural product, solasodine-3-O-β-D-glucopyranoside (SG), a steroidal alkaloid glycoside, isolated from

Two New Steroidal Glucuronides from Solanum lyratum, II1.

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Two new steroidal glucuronides of a furostanol and of a spirostanol derivative along with two known glycosides, SL-a and tigogenin 3- O-beta- D-glucopyranoside, were isolated from the aerial parts of SOLANUM LYRATUM.

Phytochemical and biological studies of Solanum schimperianum Hochst.

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Chemical reinvestigation of the aerial parts of Solanum schimperianum Hochst led to the isolation of ten compounds, lupeol (1), β-sitosterol (2), β-sitosterol glucoside (3), oleanolic acid (4), teferidin (5), teferin (6), ferutinin (7), 5-hydroxy-3,7,4'-trimethoxyflavone (8), retusin (9) and

Separation of Four Flavonol Glycosides from Solanum rostratum Dunal Using Solvent Sublation Followed by HSCCC and Low Column Temperature Preparative HPLC.

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Hyperoside, 3'-O-methylquercetin 3-O-β-D-galactopyranoside, astragalin and 3'-O-methylquercetin 3-O-β-D-glucopyranoside from an invasive weed Solanum rostratum Dunal were separated and purified successfully by high-speed counter-current chromatography (HSCCC) with a solvent system composed of

Separation of four flavonol glycosides from Solanum rostratum Dunal using aqueous two-phase flotation followed by preparative high-performance liquid chromatography.

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Aqueous two-phase flotation followed by preparative high-performance liquid chromatography was used to separate four flavonol glycosides from Solanum rostratum Dunal. In the aqueous two-phase flotation section, the effects of sublation solvent, solution pH, (NH4 )2 SO4 concentration in aqueous

Bioactive steroidal alkaloids from Solanum umbelliferum.

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Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-beta-D- glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic

Antiviral activity of Solanum paniculatum extract and constituents.

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Solanum species are traditionally employed as antiherpes and anticancer agents in different countries. S. paniculatum has widespread ethnomedical uses in Brazil, including the treatment of viral infections. This paper reports on the isolation of neotigogenin (1) and the new compound

A feeding stimulant for Manduca sexta from Solanum surattenses.

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The acceptance of Solanum surattenses as a host plant for the larvae of Manduca sexta was explained by the presence of feeding stimulants in foliage. Bioassay-guided fractionation of plant extracts resulted in the isolation of a highly active compound (1), which was identified as a furostan

Solanoflavone, a new biflavonol glycoside from Solanum melongena: seeking for anti-inflammatory components.

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A new biflavonol glycoside named as solanoflavone (1) was isolated from aerial part of Solanum melongena. The chemical structure was elucidated as isorhamnetin-3-O-beta-D-glucopyranoside-(4'-->O-->4''')-galangin-3''-O-beta-D-glucopyranoside on the basis of physicochemical and spectroscopic methods,

Steroidal alkaloid glycosides from Solanum orbignianum.

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Aerial parts of Solanum orbignianum afforded a new steroidal alkaloid glycoside, leptinidine 3-O-beta-D-glucopyranoside, together with the known alkaloids leptinidine, leptinine I and leptinine II. Their structures were established by spectroscopic methods.

New steroidal alkaloids from Solanum hypomalacophyllum.

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Two new steroidal alkaloids (1-2) have been isolated from the leaves and roots of Solanum hypomalacophyllum Bitter, respectively. Their structures have been elucidated as deacetoxysolaphyllidine-3-O-beta-D-glucopyranoside (1) and 4-keto-5,6-dihydro-(20S)-verazine (2). Furthermore, two known

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