The first group will receive Minoxidil 5% topically twice daily for 4 months.

The second group will receive NAC orally 600 mg 3 times a day for 4 months.

The third group will receive combined treatment of Minoxidil 5% twice daily and oral NAC 600 mg 3 times a day for 4 months.

The fourth group will be the patients who are refusing the treatment and will be followed-up over 4 months.

Androgenetic Alopecia

Topical 5% Minoxidil and N-Acetyl-Cysteine 600 mg orally

Minoxidil 5% topically and oral NAC 600 mg

dermatology clinics in Ain Shams University Hospital and Kafr El Sheik University Hospital.

N-Acetyl-Cysteine for Treatment of AGA in Men

Efficacy and Tolerability of N-Acetyl- Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

A photographic review of the scalp for each patient. Photos were standardized as to subject, area, distance, illumination, angle of exposure and background so that there were no major differences between any of the series of photographs. Photographs were taken using Nikon D3300 AF-P 18-55 VR 24.2 Megapixels® digital camera, based on the grading suggested by Olsen et al.,(2002) graded the photographs on a 7-point scale from dense, moderate, minimal growth, no change, minimal, moderate or dense loss. This was shown at baseline and 16 weeks of the trial.

Images were taken from fixed points in the scalp using the Dermlite П PRO HR® dermoscopy for each patient when they first presented and every month for four months. Digital images of the dermoscopic features were taken by digital camera Nikon D3300 AF-P 18-55 VR 24.2 Megapixels®. The reference points are set to the top of the vertex and a landmark for each frontal region was the intersecting point between lines passing through the ipsilateral tragus and lateral point of eyebrows. Each point was analyzed before and after follow up period by single-blinded expert in trichoscopy looking for the following parameters; total hair count, terminal hair count, vellus hair count, triple or more follicular unit, double follicular unit, single follicular unit, number of perifollicular halo (peripilar sign), thick terminal hair and thin terminal (intermediate) hair. Parameters recorded numerically then statistically analyzed for comparison between different groups of trial.

Patient satisfaction scaled from 0 if unsatisfied, 1 is mild satisfied and 2 if satisfied and compliance with treatment was documented through a patient-filled questionnaire.

Side effects of the drugs (irritation, dandruff, and hypertrichosis for minoxidil plus nausea for NAC) were documented and statistically analyzed for comparison between groups of trial.

Mohamed Abo Shabana Hussein Mohamed

Teaching Assistant of Dermatology and Venereology Department Kafrelsheikh University

Kafrelsheikh University

Ain Shams University

All participants to receive study intervention.

Retinitis Pigmentosa

After completing the pretreatment visits, all patients will enter into the treatment phase where patients will receive 1800 mg of NAC effervescent tablets twice a day. The patients will be followed up every 3 months for 2 years. Therefore, there will be a total of 9 treatment visits (baseline, months 3, 6, 9, 12, 15, 18, 21 and 24).

NAC effervescent tablets

Wilmer Eye Institute at Johns Hopkins University

FIGHT-RP 1 Extension Study

A Phase 1 Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of N-Acetylcysteine (NAC) in Patients With Retinitis Pigmentosa

Blood pressure in mmHg will be used in assessing tolerability of N-Acetylcysteine.

Participants will be assessed for the occurrence of any drug-related symptoms which includes nausea, stomach upset, diarrhea, heartburn, constipation, and vomiting. Based on the number and severity of the symptoms, the physician would conclude whether the patient is tolerating the medication or not.

Medication diary provided to participants will be reviewed to see if participants are taking the medication within the designated time frame.

Medication diary provided to participants will be reviewed to see if participants are taking the medication twice a day

Scoring is determined by the number of letters gained or lost per month using Early Treatment Diabetic Retinopathy Study (ETDRS) Letter Score and visual acuity score together with an overall score range of 0 to 20/20 where 0 is the worst vision and 20/20 is the best.

Microperimetry (MAIA) is used to test whether there is an increase or decrease in sensitivity (dB) in the retina after initiation of N-Acetylcysteine

This will be assessed by spectral domain optical coherence tomography (SD-OCT) after initiation of N-Acetylcysteine.

This will be calculated from the proportions of reduced glutathione and oxidized glutathione in the aqueous.

Johns Hopkins University

Protein 1.5 gm/kg/day, energy (kcal) 30-40/day, B complex vitamins daily. Pasteurized Bovine colostrum as a freeze dried powder (20 gm thrice a day) for 4 weeks.
+ Antibiotics + Diuretics +Terlipressin for HRS + acid suppression for prophylaxis against gastrointestinal hemorrhage + EVL for variceal bleed +drugs for HE if indicated

Protein 1.5 gm/kg/day, energy (kcal) 30-40/day, B complex vitamins daily. Placebo (Pasteurised Milk Powder) 20 gms thrice a day for 4 weeks
+ Antibiotics + Diuretics + drugs for HE + Terlipressin for HRS + acid suppression for prophylaxis against gastrointestinal hemorrhage + EVL for variceal bleed + if indicated.

Alcoholic Hepatitis

Bovine Colostrum

Placebo

Department of Gastroenterology, D.M.C. and Hospital

Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial

Change in mDF levels will be measured at baseline and after 30 days of treatment

Change in Endotoxin levels will be measured at baseline and after 4 weeks of treatment

Change in Cytokines levels will be measured at baseline and after 30 days of treatment

Number of episodes of sepsis (bacteremia, Pneumonia, SBP, Cellulitis, UTI)

Prof. Sandeep S Sidhu

Prof. Sandeep Singh Sidhu

Dayanand Medical College and Hospital

Enteral nutrition: Protein 1.5 gm/kg/day, energy (kcal) 40/kg/day, carbohydrate 67-80%, Fat 20-33%.
Oral prednisolone 40mg/day × 4 weeks and tapered to <40mg/day for next 4 weeks. If Lilli score > 0.45 after 7 days, then GC would be stopped and patients will be counselled for liver transplantation.
Oral Bovine colostrum (200 ml (20 gram) TDS × 2 months.

Severe Alcoholic Hepatitis in 'Extremis'- Defined by mDF>54

Oral Bovine colostrum 200 ml (20 gram) TDS × 2 months

Bovine colostrum

Enteral nutrition: Protein 1.5 gm/kg/day, energy (kcal) 40/kg/day, carbohydrate 67-80%, Fat 20-33%.

Enteral Nutrition

Oral prednisolone 40mg/day × 4 weeks and tapered to <40mg/day for next 4 weeks. (If Lilli score > 0.45 after 7 days, then prednisolone would be stopped)

prednisolone

Dyanand Medical College and Hospital

Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis.

Efficacy of Combination Therapy of Glucocorticoids, and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis: A Pilot Study.

Prof. Sandeep S sidhu

Methadone and N-acetylcysteine for opioids abstaining

Opioids Use

Methadone; NAC

Methadone

Taichung Veterans General Hospital

Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining

Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study

acetylcysteine/diarrhea

N-Acetyl-Cysteine for Treatment of AGA in Men

FIGHT-RP 1 Extension Study

Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial

Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis.

Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining

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