The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-alkyl-phosphinoyl-alkanes as described herein, DIPA-1-8 and DIPA-1-9, and 2-6 and 2-7 that are collectively referred to herein as "DAPA compounds", that are useful in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by inflammation, irritation, itch, or pain) in the nasal cavity. The applicant has found that localized delivery of DAPA compounds in combination with an intranasal steroid or an intranasal antihistamine immediately relieves nasal discomfort and enhances patient adherence to the use of the nasal medications.

Wei; Edward Tak

Cooling adjunct for medications to treat disorders in the nasal cavity

The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-alkyl-phosphinoyl-alkanes as described herein, DIPA-1-8 and DIPA-1-9, and 2-6 and 2-7 that are collectively referred to herein as "DAPA compounds", that are useful in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by inflammation, irritation, itch, or pain) in the nasal cavity. The applicant has found that localized delivery of DAPA compounds with a swab to the Kiesselbach's area of the human nose will relieve the discomforts of rhinitis and other nasal cavity discomforts.

Wei; Edward T.

Topical agents for the treatment of sensory discomfort in the nasal cavity

The present invention relates to an oral composition and an oral plaque dispersion agent that can effectively disperse plaque firmly adhered to a tooth surface by being applied to the oral cavity. The oral composition comprises the following components (A), (B), and (C): (A) an olefin sulfonate having 14 or more and 20 or less carbon atoms; (B) a hydroxy alkane sulfonate having 14 or more and 20 or less carbon atoms; and (C) sorbitol, wherein the content of the component (A) is 3 mass % or more and 50 mass % or less based on the total content of the component (A) and the component (B).

alkane/kaaries

Cooling adjunct for medications to treat disorders in the nasal cavity

Topical agents for the treatment of sensory discomfort in the nasal cavity

Oral composition and oral plaque dispersion agent

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