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Examination of the behavior and liver and thyroid histology of juvenile rainbow trout (Oncorhynchus mykiss) exposed to high dietary concentrations of C(10)-, C(11)-, C(12)- and C(14)-polychlorinated n-alkanes.

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Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to high dietary concentrations of six polychlorinated n-alkane (PCAs) (C(10)H(15.5)C(6.5), C(10)H(15.3)Cl(6.7),C(11)H(18.4)Cl(5.6),C(12)H(19.5)Cl(6.5),C(14)H(24.9)Cl(5.1) and C(14)H(23.3)Cl(6.7)) for 21 to assess their effects on behavior and

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis.

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Ultra-high molecular weight polyethylene is widely used as a bearing surface in prosthetic arthroplasty. Over time the generation of implant-derived wear particles can initiate an inflammatory reaction characterized by periprosthetic inflammation and ultimately bone resorption at the prosthetic bone

Acute lung injury induced by a commercial leather conditioner.

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Following a formulation change, a leather conditioner was involved in a 1992 nationwide outbreak of respiratory illness. We investigated the composition and toxicity of the conditioner produced before (previous product) and after (new product) the disease outbreak. The new product induced tachypnea,

Effect of acetaminophen on hepatic content and biliary efflux of glutathione disulfide in mice.

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The increased expiration of ethane and pentane by mice treated with hepatotoxic doses of acetaminophen suggests the possibility of oxidant mechanisms associated with the necrosis. However, studies in rats are not consistent with oxidant stress mechanisms causing the damage, because acetaminophen

Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery.

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OBJECTIVE To report the use of perfluorohexyloctane, a liquid semifluorinated alkane that is heavier than water, as an internal tamponade agent in surgery for complicated retinal detachments. METHODS A consecutive interventional case series from three study centers. METHODS In 23 consecutive eyes

Low Dose of Anisodine Hydrobromide Induced Neuroprotective Effects in Chronic Cerebral Hypoperfusion Rats.

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Chronic cerebral hypoperfusion is a common pathophysiological state in various cerebrovascular diseases. Anisodine has been reported to exert neuroprotective effects in cerebral ischemia/reperfusion (I/R) animal model. However, it is unclear whether anisodine hydrobromide, the hydrobromide format of

Protective effect of diphenylmethyl selenocyanate against CCl4-induced hepatic injury.

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Organoselenocyanates represent an important class of chemopreventive agent, which possess antioxidative, antimutagenic as well as cancer chemopreventive properties. The present study is an attempt to evaluate the protective effect of diphenylmethyl selenocyanate -- a synthetic organoselenocyanate

Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model.

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The use of many halogenated alkanes such as carbon tetrachloride (CCl4), chloroform (CHCl3) or iodoform (CHI3), has been banned or severely restricted because of their distinct toxicity. Yet CCl4 continues to provide an important service today as a model substance to elucidate the mechanisms of

Tissue PAH, blood cell and tissue changes following exposure to water accommodated fractions of crude oil in alligator gar, Atractosteus spatula.

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Alligator gar Atractosteus spatula acclimated to brackish water (9 ppt) were exposed to water accommodated fraction oil loadings (surrogate to Macondo Deepwater Horizon, northern Gulf of Mexico) of 0.5 and 4.0 gm oil/L tank water for 48 h. The surrogate oil was approximately 98% alkanes and alkynes

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib.

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BACKGROUND XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by

Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles.

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BACKGROUND Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of

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