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Leht 1 alates 16 tulemused
Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Exposure of rats to a reduced oxygen tension (6% O2, 94% N2) for 6 h increased the serum enzyme and the histological lesions induced by carbon tetrachloride (CCl4). Hypoxia did not enhance the hepatotoxic response to paracetamol, allyl alcohol, bromobenzene or thioacetamide. No correlation was found
Effects of 2-allophanyl-2-allyl-4-valerolactone (valofan) on cerebral energy metabolism of rat in normoxia and hypobaric hypoxia.
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Logi sisse
The effects of an atypical barbiturate, valofan, and of a classical barbiturate, exobarbital, on the cerebral energy metabolism of rat have been evaluated under normoxic and hypobaric hypoxia conditions. In hypobaric hypoxia, the survival time was significantly increased by valofan 1.5 g/kg and
[N-allyl-normorphine in hypoxia secondary to maternal morphine treatment].
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Logi sisse
Effect of hepatotoxic chemicals and hypoxia on hepatic nonparenchymal cells: impairment of phagocytosis by Kupffer cells and disruption of the endothelium in rat livers perfused with colloidal carbon.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Kupffer cells play an important role in liver function and phagocytosis of foreign particles in the hepatic portal tract. Therefore, the purpose of this study was to investigate the influence of several hepatotoxic chemicals (allyl alcohol, ethylhexanol, and menadione) and hypoxia on phagocytic
The effects and underlying mechanisms of S-allyl l-cysteine treatment of the retina after ischemia/reperfusion.
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Logi sisse
OBJECTIVE
Retinal ischemia-associated ocular disorders are vision-threatening. The aim of the present study was to examine whether S-allyl l-cysteine (SAC) is able to protect against retina ischemia/reperfusion injury.
METHODS
In vivo, retinal ischemia in the rat was induced by raising intraocular
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.
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Logi sisse
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits. HIF-1 is critically involved in cellular responses to hypoxia, glycolysis, and angiogenesis. Here, we show that treatment of prostate cancer PC-3 and LNCaP cells with the benzoquinone
Cytoprotective effects of myristicin against hypoxia‑induced apoptosis and endoplasmic reticulum stress in rat dorsal root ganglion neurons.
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Logi sisse
The aim of the present study was to investigate the role of myristicin (Myr; 1‑allyl‑5‑methoxy‑3,4‑methylenedioxybenzene), an active aromatic compound isolated from nutmeg, carrot, basil, cinnamon and parsley, in hypoxia‑induced apoptosis in rat dorsal root ganglion (DRG) neurons. It was observed
Effects of some -OH scavengers on the radiation sensitization of bacterial spores by p-nitroacetophenone and O2 in suspension.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Spores of Bacillus megaterium were irradiated in suspension with 50 kVp X-rays under three reference conditions: in anoxia (i.e., 100 per cent N2); in anoxia with 2mM p-nitroacetophenone (PNAP), a concentration that shows the maximum amount of sensitization by this agent; and in air. The responses
Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxygenation phase.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The present study investigated the temporal relationship between neuronal nitric oxide synthase (nNOS) activity and expression and the development of neuronal damage occurring during anoxia and anoxia followed by reoxygenation. For this purpose, cerebellar granule cells were exposed to 2 hr of
Indole conjugated silica and magnetic nanoparticles as inhibitors of HIF.
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Logi sisse
Multifunctional silica nano-vehicles (SiO2@indol-IL) and magnetic nanoparticles (Fe3O4@indol-IL) were constructed through the Schiff bases condensation of indole-3-carboxaldehyde and 4-acetyl-N-allyl pyridinium chloride (ILs) with the amine groups of silica and magnetic nanoparticles. SiO2@indol-IL
The acute effects of S-(1,2-dichlorovinyl)-L-cysteine and related chemicals on renal function and ultrastructure in the pentobarbital-anesthetized dog: structure-activity relationships, biotransformation, and unique site-specific nephrotoxicity.
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Logi sisse
S-(1,2-Dichlorovinyl)-L-cysteine (L-DCVC), a substrate for the renal cysteine conjugate beta-lyase, and other related chemicals were administered intravenously to pentobarbital-anesthetized dogs. Six pertinent findings emerged regarding their nephrotoxicity. (1) L-DCVC was acutely nephrotoxic in the
Mitochondrial respiratory chain as a new target for anti-ischemic molecules.
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Logi sisse
Vascular diseases like thrombosis, myocardial infarction, cerebral ischemia or chronic venous insufficiency affect a high proportion of the population. They are all associated with more or less pronounced ischemic conditions. We have previously shown that some venotropic drugs display an
[Mechanisms of the protective effect of methohexital on cerebral energy metabolism].
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Logi sisse
The purpose of the present investigation was to study the effect of alpha-(+/-)-5-allyl-1-methyl-5-(1-methyl-2-pentinyl) barbituric acid (methohexital, Brevimytal sodium) on brain energy metabolism. The model of the isolated perfused rat brain was used. The high-energy phosphates, some substrates of
Influence of 2,4-dinitrophenol on the susceptibility of rats to hepatotoxic injury.
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Logi sisse
Treatment of rats with 2,4-dinitrophenol (DNP) markedly enhanced the release of enzymes into serum induced by carbon tetrachloride (CCl4). DNP also aggravated the hepatotoxic response to paracetamol but not that to allyl alcohol, bromobenzene and thioacetamide. DNP-induced hypoxia resulting in an
The Pharmacological Effects of S-Propargyl-Cysteine, a Novel Endogenous H2S-Producing Compound.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
S-propargyl-cysteine (SPRC), also named as ZYZ-802, is a structural analog of S-allylcysteine (SAC), the most abundant constituent of aged garlic extract. SPRC becomes a derivative of the amino acid cysteine, which contains sulfur atom, by changing allyl group in SAC to propargyl group in SPRC.
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