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Leht 1 alates 31 tulemused
The association of post-stroke anhedonia with salivary cortisol levels and stroke lesion in hippocampal/parahippocampal region.
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BACKGROUND
Anhedonia constitutes a coherent construct, with neural correlates and negative clinical impact, independent of depression. However, little is known about the neural correlates of anhedonia in stroke patients. In this study, we investigated the association of post-stroke anhedonia with
Anhedonia and activity deficits in rats: impact of post-stroke depression.
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Logi sisse
Animal models may allow investigation into the aetiology and treatment of various human disorders. In the present study, a rat model for post-stroke depression (PSD) has been developed using middle cerebral artery occlusion (MCAO), followed by an 18-day chronic mild stress (CMS) paradigm in
Unconventional affective symptoms and executive functions after stroke in the elderly.
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Logi sisse
In the present study we assessed the presence and severity of unconventional affective symptoms (apathy, anhedonia and emotional lability) and depression in 33 elderly patients with first ever stroke and evidence of a single supratentorial lesion at neuroimaging. Patients were submitted to
Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the post-stroke depressive state in rats.
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Logi sisse
OBJECTIVE
To evaluate the feasibility of focal cerebral ischemia and reperfusion (FCIR) surgery combined chronic unpredictable mild stress (CUMS) to simulate the post-stroke depression (PSD) state in rats.
METHODS
Sprague-Dawley male rats were divided randomly into five groups: the normal, sham,
Is bupropion useful in the treatment of post-stroke thalamic apathy? A case report and considerations.
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Logi sisse
Post-stroke apathy is considered to be one of the clinical consequences of lesions affecting the structures of the prefrontal cortex, basal ganglia, thalamus and limbic system. However, there is no current consensus on the treatment of post-stroke apathy, which mainly depends on the underlying
Antidepressant Effects of Aripiprazole Augmentation for Cilostazol-Treated Mice Exposed to Chronic Mild Stress after Ischemic Stroke.
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Logi sisse
The aim of this study was to determine the effects and underlying mechanism of aripiprazole (APZ) augmentation for cilostazol (CLS)-treated post-ischemic stroke mice that were exposed to chronic mild stress (CMS). Compared to treatment with either APZ or CLS alone, the combined treatment resulted in
Behavioral effects of 2,3-dihydro- and oxoisoaporphine derivatives in post stroke-depressive like behavior in male BALB/c mice.
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Logi sisse
In this study, antidepressant-like effects of intra-cerebroventricularly administration of oxoisoaporphine derivatives in post stroke-depressive like behavior were examined through despair swimming and tail suspension models. For this aim, acute ischemic stroke was induced by bilateral common
bi-3-azaoxoisoaporphine derivatives have antidepressive properties in a murine model of post stroke-depressive like behavior.
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Logi sisse
In the present study, three bi-3-azaoxoisoaporphine derivatives were synthesized and intracerebroventricularly administrated to BALB/c mice. The antidepressant actions in stroke-induced depressive like behavior in mice were examined using despair swimming test and tail suspension test. The results
The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats.
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Logi sisse
Poststroke depression (PSD) is the most common psychological sequel after stroke. Although the neurological mechanisms of PSD remain to be fully elucidated, numerous studies have implicated the calcitonin gene-related peptide (CGRP), a potent vasodilatory neuropeptide, as key modulator of the
Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression
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Logi sisse
Elucidation of the pathogenic mechanisms underlying post-stroke depression (PSD) could aid in the development of effective treatments. The present study explored whether Vitamin D3 (VitD3) can function as an antidepressant in PSD model mice and whether the effect is mediated by upregulation of
Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats.
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Logi sisse
Poststroke depression is one of the major symptoms observed in the chronic stage of brain stroke such as cerebral ischemia. Its pathophysiological mechanisms, however, are not well understood. Using the transient right middle cerebral artery occlusion- (MCAO-, 90 min) operated rats as an ischemia
Agomelatine: an agent against anhedonia and abulia?
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Logi sisse
Anhedonia and abulia are syndromes often presented as components of various psychiatric and neurological disorders, including depression, schizophrenia, stroke, multiple sclerosis and brain injury. On the basis of the hypothesis that alterations in the dopaminergic motivational system might be
Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression.
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Logi sisse
Ischemia-stimulated dentate gyrus (DG) neurogenesis is hypothesized to be an etiological factor of post-stroke depression (PSD) and a potential target of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) in PSD. Clinical investigations have explored the strategy of
[Establishment of rat model of post-stroke depression and the effects of citalopram on behavior thereof].
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Logi sisse
OBJECTIVE
To establish an animal model of post-stroke depression (PSD) and assess the effects of citalopram on PSD.
METHODS
Fifty-two male SD rats were randomly divided into 3 groups. Normal group (n = 6) underwent sham operation. Chronic unpredictable mild stress (CMS) group (n = 6), underwent
[The Post Stroke Depression Scale (PSDRS) as a tool for evaluation of depressed mood at an early stage after cerebral stroke].
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Logi sisse
Cerebral stroke can lead both to the limitation of motor skills and cognitive dysfunctions as well as mood disorders. One of the most frequent results of cerebral stroke is post-stroke depression (PSD). Numerous researchers have emphasized the significance of an early detection of this disorder.
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