Depressive Disorder

Anhedonia

Ezogabine

Placebos

Icahn School of Medicine at Mount Sinai

Baylor College of Medicine

Study to Treat Major Depressive Disorder With a New Medication

Developing Neuronal KCNQ Channel Modulators for Mood Disorders

Change in the cortico-striatal circuit response to reward after at least one week treatment with the maximum dosage of ezogabine at baseline and after 5 weeks of treatment.

14-item self-report questionnaire commonly used to assess anhedonia.

A widely administered clinician rated global measure of the degree of improvement from the initial assessment in subject overall illness severity.

Clinician rated global measure of subject overall illness severity.

A measure specifically designed to assess hedonic capacity for social and interpersonal pleasure.

A 10-item instrument used for the evaluation of depressive symptoms in adults and for the assessment of any changes to those symptoms.

A 12-item generic assessment instrument that measures investigating the level of functioning in six domains: Cognition, Mobility, Self-care, Getting along, Life activities, and Participation.

The TEPS is an 18-item self-report measurement of anticipatory (10 items) and consummatory (eight items) components of anhedonia which consists of a series of statements that must be rated according to how accurate they are for the individual.

The SLIPS is a recently developed and validated measure of anhedonia that is tailored to detect recent changes in anhedonia.

Data from this study may be submitted to the National Database for Clinical Research Related to Mental Illness (NDCT). NDCT isa data repository run by the National Institute of Mental Health (NIMH) that allows researchers studying mental illness to collect and share deidentified information with each other. During and after the study, the researchers will send deidentified information about health and behavior and in some cases, genetic information, to NDCT. Other researchers nationwide can then file an application with the NIMH to obtain access to deidentified study data for research purposes.

James Murrough

Associate Professor

National Institute of Mental Health (NIMH)

Mindfulness Training for Smokers (MTS) is a 7-week intervention that provides instruction in mindfulness very similar to the way it is taught in Mindfulnes-Based Stress Reduction. In addition MTS provides mindfulness training targeted to specific smoking relapse challenges. The MTS intervention was designed around a weekly curriculum that provides instruction to help participants learn practices including mindfulness meditation, mindful walking and mindful eating. MTS participants are instructed to practice meditation 30 minutes per day with a guided meditation CD.

Interactive Learning for Smokers (ILS) is a 7-week intervention that provides a closely matched active control group for MTS, but with substantive education and skills training for smoking cessation. To this end, ILS combines elements of two smoking cessation programs, the American Lung Association, Freedom from Smoking program and The Mayo Clinic Nicotine Dependence Center program. ILS participants were asked to practice 30 minutes of silent non-directed walking per day throughout the intervention and were instructed to use non-directed walking for relaxation, stress reduction and as a strategy for managing urges and withdrawal symptoms.

Mindfulness Training for Smokers (MTS) is a 7-week intervention that provides instruction in mindfulness very similar to the way it is taught in Mindfulnes-Based Stress Reduction. In addition MTS provides mindfulness training targeted to specific smoking relapse challenges. The MTS intervention was designed around a weekly curriculum that provides instruction to help participants learn practices including mindfulness meditation, mindful walking and mindful eating. MTS participants are instructed to practice meditation 30 minutes per day with a guided meditation CD.
Mindfulness Training for Smokers: The provides the Mindfulness Training for Smokers intervention (7 weeks long).

Mindfulness Training for Smokers

Interactive Learning for Smokers (ILS) is a 7-week intervention that provides a closely matched active control group for MTS, but with substantive education and skills training for smoking cessation. To this end, ILS combines elements of two smoking cessation programs, the American Lung Association, Freedom from Smoking program and The Mayo Clinic Nicotine Dependence Center program. ILS participants were asked to practice 30 minutes of silent non-directed walking per day throughout the intervention and were instructed to use non-directed walking for relaxation, stress reduction and as a strategy for managing urges and withdrawal symptoms.
Interactive Learning for Smokers: This provides the Interactive Learning for Smokers intervention (7 weeks long).

Interactive Learning for Smokers

Total

Sex: Female, Male

Region of Enrollment

Smoking abstinence is measured by Carbon Monoxide Breath Testing in Controls vs Study Group subjects two weeks after the quit day

Smoking Abstinence

Timeline follow back participant self-report of daily alcohol use.

Alcohol Use in Study Subjects vs Controls

Overall Study

James M. Davis MD, Assistant Professor, Duke University

Nicotine Dependence

Alcohol Use

The provides the Mindfulness Training for Smokers intervention (7 weeks long).

This provides the Interactive Learning for Smokers intervention (7 weeks long).

anhedonia/seizures

Study to Treat Major Depressive Disorder With a New Medication

Pilot Study on Mindfulness for Tobacco and Alcohol in University Students

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