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apomorphine/oksendamine

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Leht 1 alates 275 tulemused
OBJECTIVE To describe the use of sodium carbonate and apomorphine in a historical cohort of dogs, compare the occurrence of emesis and report any adverse effects recorded. METHODS This historical, observational study included information from medical records of dogs that received an emetic agent.

The influence of propofol on vomiting induced by apomorphine.

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Logi sisse
It has been proposed that propofol has antiemetic effects even in nonsedative doses. The aim of this study was to investigate whether propofol influences vomiting induced by the dopamine agonist apomorphine. Ten healthy male volunteers received apomorphine infusion (1 mg/min) until vomiting was

Betamethasone does not prevent nausea and vomiting induced by the dopamine-agonist apomorphine.

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Logi sisse
OBJECTIVE The mechanism of the antiemetic actions of corticosteroids is not known. The purpose of this study was to evaluate if betamethasone can prevent nausea, vomiting or increase of vasopressin induced by apomorphine. Metoclopramide, a dopamine antagonist, was used as a control
The effects of diphenhydramine, domperidone, ondansetron, and diphenidol on motion- and apomorphine-induced pica (i.e., kaolin ingestion) in rats as the measure analogous to emesis in other species were examined. Diphenhydramine (10 and 20 mg/kg) and diphenidol (30 mg/kg) inhibited kaolin intake
Small rodents (mice, rats) are the species of choice for evaluating the pharmacology of centrally acting compounds, such as antipsychotics, whereas toxicology data are routinely obtained from other species (rabbits, dogs, monkeys). Whilst there is a substantial number of "therapeutically relevant"
OBJECTIVE Morphine can have either an emetic or an antiemetic effect. The emetic effect of morphine can be blocked by methylnaltrexone (MNTX), a quaternary opioid antagonist with peripheral action. In this study, we tested the hypothesis that administering MNTX to block the peripheral emetic effect

Gastric relaxation and vomiting by apomorphine, morphine and fentanyl in the conscious dog.

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Logi sisse
Apomorphine (0.03 mg . kg-1 s.c.) and morphine (0.5 mg . kg-1 s.c.) produced gastric relaxation and vomiting in the conscious dog. Domperidone (0.1-1 mg . kg-1 i.v.), haloperidol (0.1 mg . kg-1 i.v.) and pimozide (0.025 mg . kg-1 i.v.) selectively blocked the gastric relaxation as well as the

Central mechanisms for apomorphine-induced emesis in the dog.

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Logi sisse
In order to investigate whether different receptor populations mediate emesis induced by intracerebroventricular (i.c.v.) and intravenous (i.v.) apomorphine, adult beagle dogs were tested with various doses of the drug with and without central and peripheral pretreatment with the dopamine antagonist

Long term effect of teflutixol on apomorphine-induced stereotypy and vomiting in dogs.

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Logi sisse
Dose--response relationships to apomorphine-induced vomiting and stereotyped running behaviour have been determined in dogs before, and up to 24 and 28 days respectively, after daily oral treatment with 2.5 mg/kg of teflutixol or 12 days. The ED50 values for apomorphine-induced vomiting after

Naloxone does not prevent apomorphine-induced emesis or hypotension in dogs.

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Logi sisse
Previous data have shown that apomorphine-induced respiratory depression can be reversed by the opiate antagonist, naloxone. The present study investigates the influence of naloxone on cardiovascular changes and vomiting elicited by apomorphine in dogs. In chloralose-anaesthetized animals, naloxone

Internal vomiting in the ruminant: effect of apomorphine on ruminal pH in sheep.

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Logi sisse
Five sheep, with a rumen fistula inserted, were each injected (IV) with apomorphine (18 mg) and ruminal pH was measured every 5 minutes during a 1-hour period. During the base-line period (30 minutes) that preceded apomorphine injection, pH was constant in individual sheep and te group mean (+/- SD)

Safety and efficacy of an ocular insert for apomorphine-induced emesis in dogs.

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Logi sisse
OBJECTIVE To evaluate the safety and efficacy of an ocular insert designed to provide controlled release of apomorphine for the induction of emesis in dogs. METHODS 5,001 dogs treated with ocular apomorphine inserts and 32 dogs treated with IV administration of apomorphine. METHODS Data collected on

Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret.

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Logi sisse
The action of domperidone (1 mg/kg, i.p.) on spontaneous behaviour and the emesis and behavioural change induced by apomorphine (0.25 mg/kg, s.c.) were studied in the ferret. Domperidone was inactive to modify spontaneous behaviour but apomorphine-induced emesis and increased locomotor activity
These studies have examined the effects of the selective neurokinin1 (NK1) receptor antagonist CP-99,994 on the retching and vomiting response to apomorphine. CP-99,994 (1-3 mg/kg i.p.) attenuated retching and vomiting induced by apomorphine (0.25 mg/kg s.c.) with complete inhibition of retching and

Apomorphine-induced vomiting in rainbow trout (Salmo gairdneri).

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Logi sisse
1. The LD50 for a 7-day period following intraperitoneal injection of apomorphine-HCl was calculated to be 158 mg/kg in rainbow trout. 2. Intraperitoneal injection of apomorphine at doses of 60 mg/kg or greater caused vomiting of plastic balls which had been placed in the stomachs of rainbow trout.
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