Adjunctive 200 mcg Transdermal Estradiol

Adjunctive 100 mcg Transdermal Estradiol

Placebo

Total

Sex: Female, Male

Region of Enrollment

The Positive and Negative Syndrome Scale (PANSS) is a well validated, standardized method of evaluating and monitoring psychotic symptoms. The PANSS assesses: positive (hallucinations, delusions, thought disorder), negative (blunted affect, abstract thinking and general symptomatology. The positive and negative subscale each consist of 7 items rated from 1(absent) - 7(extreme) with a minimum score = 7, maximum score = 49. The general subscale consists of 16 items with a minimum score = 16, maximum score = 112. A Total PANSS score (positive+ negative + general scores) has a minimum of 30 and maximum of 210. Higher scores represent more severity in symptoms.

Participants received daily 200 mcg transdermal estradiol for 56 days.

Participants received daily 100 mcg transdermal estradiol for 56 days.

Participants received daily transdermal placebo for 56 days.

Positive and Negative Syndrome Scale (PANSS)

Cognitive Performance (RBANS Scores)

Scores on MADRS at Trial Completion

Scores on Adverse Symptom Checklist at Trial Completion

Change in Hormone Levels Over Trial Duration

Participants received daily 200mcg transdermal estradiol for 56 days.

Participants received daily 100mcg transdermal estradiol for 56 days.

Overall Study

Prof Jayashri Kulkarni

Participants received daily 200mcg transdermal estradiol for 8 weeks (56 days).

Participants received daily 100mcg transdermal estradiol for 8 weeks (56 days).

Participants received daily transdermal placebo for 8 weeks (56 days).

Schizophrenia

Schizoaffective Disorder

Schizophreniform Disorder(Not in Manic Phase)

Estradiol

placebo

Bayside Health - The Alfred Hospital

A Definitive Estrogen Patch Study (ADEPT)

Multisite Double-Blind Randomized Controlled Study of Estradiol Plus Antipsychotic Versus Placebo Plus Antipsychotic in the Treatment of Psychotic Symptoms in Women With Schizophrenia

apomorphine/rinnavähk

A Definitive Estrogen Patch Study (ADEPT)

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