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bronchiectasis/proline

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Cystic fibrosis (CF) is chronic lung disease characterized by an unrelenting neutrophil-predominant airway inflammatory response. This inflammation leads to extracellular matrix (ECM) remodeling and eventually to the development of bronchiectasis. While many components of the immune response in CF

Pseudomonas aeruginosa adherence to human basement membrane collagen in vitro.

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Logi sisse
The mechanisms for Pseudomonas aeruginosa colonisation in the airways of patients with bronchiectasis and cystic fibrosis are poorly understood. P. aeruginosa could evade mucociliary clearance by adhering to the basement membrane at areas denuded of intact respiratory epithelium. The authors have

Pseudomonas aeruginosa hemolytic phospholipase C suppresses neutrophil respiratory burst activity.

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Pseudomonas aeruginosa is a persistent pathogen in the airways of patients with cystic fibrosis or bronchiectasis from other causes and appears to have evolved strategies to survive the inflammatory response of the host. We hypothesized that the secreted hemolytic phospholipase C (PLC) of P.

Sputum proteomics in inflammatory and suppurative respiratory diseases.

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BACKGROUND Markers of inflammatory activity are important for assessment and management of many respiratory diseases. Markers that are currently unrecognized may be more valuable than those presently believed to be useful. OBJECTIVE To identify potential biomarkers of suppurative and inflammatory
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