Leht 1 alates 182 tulemused
OBJECTIVE
Vascular endothelial growth factor (VEGF) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), but its site-specific expression in lung tissue and the relationship with hypoxia inducible factor-1 alpha (HIF-1α) expression in chronic bronchitis (CB) type
The authors review the main physiological alterations occurring in the body under the influence of hypoxia. Provide the data on successful use of the method in the treatment of a number of diseases with a purpose of increasing nonspecific resistance of the body. Based on the review of literature
Patients with chronic bronchitis and emphysema who are hypoxic when awake become more hypoxic during sleep, with a further rise in their preexisting pulmonary hypertension. Almitrine, a respiratory stimulant, improves arterial blood gas tensions in such patients when they are awake. We have used a
Hypoxic pulmonary vasoconstriction is considered as one of the factors leading to pulmonary hypertension in patients with chronic bronchitis, but the magnitude and the variability of the pulmonary vascular response to hypoxia in these patients have not been well established. We investigated the
OBJECTIVE
Vectorcardiography (VCG) QRS loop area is thought to reflect hemodynamic abnormalities in cardiac lesions. The aim of the present study was to evaluate the response of VCG QRS loop area and intrapulmonary flow (PF) to acute hypoxia in patients with chronic bronchitis (CB) and pulmonary
In a double-blind placebo controlled randomised study, the effects of almitrine bismesylate on the sleep induced Hb desaturations, associated or not with disorders of breathing, were tested. Patients (37-75 yrs, 8M and 2F) were affected by chronic bronchitis (out of any exacerbation) and obesity
Experimental evidence from animals suggests that the response of the pulmonary circulation to hypoxia is mediated by histamine. In 3 patients with chronic bronchitis the pulmonary vascular response to hypoxia was measured before and after administration of chlorpheniramine, a competitive antagonist
In five patients with hypoxic chronic bronchitis and emphysema we measured ear O2 saturation (SaO2), chest movement, oronasal airflow, arterial and mixed venous gas tensions, and cardiac output during nine hypoxemic episodes (HE; SaO2 falls greater than 10%) in rapid-eye-movement (REM) sleep and
BACKGROUND
COPD is a heterogeneous disease composed by two main phenotypes: bronchitis (COPDb) and emphysema (COPDe) with different clinical presentation, physiology, imaging, response to therapy and decline in lung function. The aim of this study is to evaluate whether nocturnal hypoxemic COPDb and
The measurement of arterial blood oxygen tension (PaO2) in 54 patients with chronic nonspecific lung disease with a FEV1.0 of 1.51 or less, in a stable clinical state, at rest, indicated subnormal results to be more frequent among "bronchitics" (79 per cent with hypoxemia) than than among
The results of intermittent normobaric hypoxytherapy in 42 patients with bronchial asthma (BA) and 14 patients with chronic obstructive bronchitis (COB) are analyzed. The positive effect is obtained in 76% of patients with BA and 92.8% of patients with COB. In the group of patients with BA the best