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cardiotoxicity/turse
Link salvestatakse lõikelauale
Leht 1 alates 195 tulemused
[Cardiac toxicity and edema].
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Logi sisse
Anticancerdrug-induced cardiac toxicity has been recognized since the introduction and widespread use of the anthracycline derivative doxorubicin in the 1970's. Risk factors for cardiac toxicity have increased along with the development of multidisciplinary therapy, high-dose combination
Pulmonary edema as a complication of interleukin-2 therapy.
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Logi sisse
Eight patients underwent IV bolus therapy with recombinant interleukin-2 (Cetus Corporation, Emeryville, CA) for treatment of metastatic melanoma or renal cell carcinoma. The patients were randomized to receive interleukin-2 alone or interleukin-2 in combination with lymphokine-activated killer
Characterization of cardiotoxicity induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin and related chemicals during early chick embryo development.
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Cardiotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied in White Leghorn-Babcock (WLB) and Plymouth Rock-Barred (PRB) chick embryos. TCDD, injected on day 0 (D0), induced a dose-related increase in heart weight in both strains in the absence of pericardial edema on D10. PRB embryos
Cardiotoxicity of Senna occidentalis in sheep (Ovis aries).
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The cardiotoxicity of Coffee senna (Senna occidentalis) was investigated in sheep that were fed diets containing its seeds, which are recognized as the most poisonous part of such weed. Dianthrone, the main toxic component of S. occidentalis, is known to impair mitochondrial oxidative
Fatal Cerebral Edema, Seizures, and Hyponatremia After Trazodone Overdose.
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Trazodone is a serotonin antagonist and reuptake inhibitor that is widely used for the treatment of depression and insomnia. Fatal overdose is rare and usually occurs when combined with other drugs or alcohol. Only a few lethal cases of pure trazodone overdose have been reported, all attributed to
Cardiotoxicity of human recombinant interleukin-2 in rats. A morphological study.
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BACKGROUND
One of the side effects of interleukin 2 (IL-2) cancer immunotherapy in humans is the vascular leak syndrome, which is frequently associated with depression of myocardial function, myocarditis, and myocardial necrosis.
RESULTS
To investigate this cardiotoxicity, IL-2 (three doses of 5 x
Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos.
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Halogenated carbazoles are increasingly identified as a novel class of environmental contaminants. However, no in vivo acute toxicity information on those compounds was available. In the present study, an in vivo zebrafish embryonic model (Danio rerio) was used to investigate the developmental
Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development.
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Logi sisse
Petroleum-derived compounds, including polycyclic aromatic hydrocarbons (PAHs), commonly occur as complex mixtures in the environment. Recent studies using the zebrafish experimental model have shown that PAHs are toxic to the embryonic cardiovascular system, and that the severity and nature of this
Low-dose methotrexate-induced vulvar edema: A case report.
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Pheochromocytoma-induced acute pulmonary edema and reversible catecholamine cardiomyopathy mimicking acute myocardial infarction.
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Acute noncardiogenic pulmonary edema and catecholamine-induced cardiomyopathy as the first presentations of pheochromocytoma are uncommon events, but usually rapidly fatal. A 36-year-old man presented acute pulmonary edema in a setting of hypertensive emergency after arthroscopy, later developing
[A comparative study of 4'-epi-doxorubicin and doxorubicin cardiotoxicities].
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The cardiotoxicities of 4'-epidoxorubicin (4-epiDX) and doxorubicin (DX) were compared in rabbits. Thirty-one male NZW rabbits weighing 2.4 to 2.6 kg were used for each compound and 15 were kept as controls. DX or 4'-epiDX was administered intravenously with a dose of 0.8 mg/kg for 3 consecutive
[Cardiotoxicity study of ME2303 with the interval intravenous injections to rats].
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Logi sisse
Cardiotoxic effects of ME2303 were studied upon interval intravenous administrations to rats in comparison with those of doxorubicin (ADR). ME2303 at two dose levels of 3 and 9 mg/kg/day or ADR at a dose levels of 3 mg/kg/day was injected once a week for 3 weeks to female Sprague-Dawley rats (SPF)
Cardiotoxicity as a dose-limiting factor in a schedule of high dose bolus therapy with interleukin-2 and alpha-interferon. An unexpectedly frequent complication.
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BACKGROUND
In a group of patients with metastatic melanoma treated with high dose immunotherapy, there was an unexpectedly high incidence of severe cardiac adverse effects.
METHODS
Sixteen patients with metastatic melanoma were treated with high dose interleukin-2 (IL-2) and alpha-interferon
[Assessment of cardiotoxicity of high dose cyclophosphamide with electrocardiographic, echocardiographic, and troponin I monitoring in patients with breast tumors].
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BACKGROUND
High-dose cyclophosphamide is the nucleus for virtually all high-dose chemotherapy protocols. Non-hematologic dose-limiting toxicity is represented by acute cardiomyopathy, even fatal in a minority of patients. The pathophysiology of such a cardiotoxicity is still poorly understood.
Assessment of Pregabalin-Induced Cardiotoxicity in Rats: Mechanistic Role of Angiotensin 1-7.
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Logi sisse
Pregabalin (PRG) possesses great therapeutic benefits in the treatment of epilepsy, neuropathic pain, and fibromyalgia. However, clinical data have reported incidence or exacerbation of heart failure following PRG administration. Experimental data exploring cardiac alterations and its underlying
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