The present invention inter alia provides a method, and use thereof, of predicting CV complications such as AMI, ACS, stroke, and CV death by determining the concentrations of at least one ceramide of Group A and at least one ceramide of Group B in a biological sample and comparing those concentrations to a control. Finding a decreased concentration of at least one Group A ceramide and an increased concentration of at least one Group B ceramide indicates that the subject has an increased risk of developing one or more CV complications. Also provided are a newly identified subset of ceramide molecules, labelled versions thereof, and kits and compositions comprising the same for use in predicting and/or diagnosing CV complications.

ZORA BIOSCIENCES, OY

Ceramides and their use in diagnosing CVD

The present invention inter alia provides a method, and use thereof, of predicting CV events such as AMI, ACS, stroke, and CV death by determining the concentration of at least one ceramide of Formula I or one lysophospholipid of Formula II and/or III and at least one lysophospholipid of Formula IV, V, VI, VII and/or VIII in a biological sample and comparing those concentrations to a control. Finding an increased concentration of the at least one Formula I ceramide or Formula II and/or III lysophospholipid and a decreased concentration of the at least one Formula IV, V, VI, VII and/or VIII lysophospholipid indicates that the subject has an increased risk of developing one or more CV events. The present disclosure also provides a method, and use thereof, of diagnosing subjects suffering acute ischemia. Also provided are kits and compositions comprising the same for use in predicting and/or diagnosing CV events.

Zora Biosciences OY

Use of ceramides and LPLs in diagnosing CVD

The present invention relates to a novel target to control the apoptotic process, and to the use of this target to identify compounds capable of affecting the apoptotic process, The invention also relates to the use of such identified compounds in the treatment of cancer, stroke, neurodegenerative diseases, viral diseases and other diseases and conditions involving apoptosis.

ceramide/insult

Ceramides and their use in diagnosing CVD

Ceramides and their use in diagnosing CVD

Use of ceramides and LPLs in diagnosing CVD

Control of apoptosis by controlling the propensity of ceramide channel formation

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