400 mg oral proplois (capsule) was given to participants once daily for 6 months after performing scaling and root planing.

Placebo capsule was given to participants once daily for 6 months after performing scaling and root planing.

Diabetes Mellitus

Periodontitis

Propolis capsules was taken by the experimental group for 6 months after receiving scaling and root planing (SRP).

Propolis

Placebo capsules was taken by the control group for 6 months after receiving scaling and root planing (SRP).

Placebo

Faculty of Dentistry

Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis

Propolis Improves Periodontal Status and Glycemic Control in Subjects With Type 2 Diabetes Mellitus and Chronic Periodontitis: a Randomized Clinical Trial

HbA1c was evaluated at baseline,3 and 6 months

Mohamed Anees

Lecturer of Oral Medicine and Periodontology

Mansoura University

100% shea nut oil extract with 75% triterpene esters. Daily dosage is three 750 mg soft gel capsules (2250 mg/per day) taken in the morning for 3 months

placebo which comprised 100% canola oil or starch mixed soybean oil

Hemophilia

Hemophilic Arthropathy

shea nut oil extract

Hemophilia care and research center

Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy

The pain intensity will be evaluated subjectively on a visual analogue scale (0-100mm).

C-telopeptide fragments of type II collagen (CTX-II) in urine is a measure of type II collagen degradation and a biological marker of arthropathy.

TNF-alpha are one of inflammatory mediators that increase following hemarthrosis in hemophilic mice. Plasma samples will tested by ELISA.

Synovial thickness (mm) by ultrasonography were evaluated from the lateral, middle, and medial aspects of the anterior suprapatellar recess

Power Doppler assessment of selected synovial sites is carried out with settings standardized to a pulse repetition frequency of 700 Hz. The intensity of the blood flow in the synovium is scored into 0 to 3 (0=No flag; 1 = 1 flag; 2 = 2-3 flags; 3=>3 flags) adapted from Klukowska and Melchiorre et al

The SF-36 is filled out taking into account the person's condition in the last one month and scores range from 0 to 100, with higher scores indicating better health-related quality of life.

The HJHS is a structured physical examination score evaluating the joint health in hemophilia patient. The score for each joint is the sum of the individual items including swelling, swelling duration, muscle atrophy, axial alignment, crepitus of motion, flexion loss & extension loss, joint pain and strength. A score of 20 suggests the worst possible damage/impairment in the evaluating joint.

cinnamic acid/hemorrhage

Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis

Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy

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