The African tree Combretum caffrum (Combretaceae) has been found to contain an agent which is a powerful inhibitor of tubulin polymerization (IC50 2-3 .mu.M), the growth of murine lymphocytic leukemia (L1210 and P388 with ED50 &lt;0.003 mg/ml and human colon cancer cell lines (e.g. VoLo with ED50 &lt;0.01 .mu.g/ml). This agent is herein denominated "combretastatin A-4". The structure assigned by spectral techniques was confirmed by synthesis.

Arizona Board of Regents

combretum adenogonium/leukeemia

Combretastatin A-4

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